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research / researchCancer RNA Biology

Robert K. Bradley

罗伯特·布拉德利

PhD

🏢Fred Hutchinson Cancer Center(弗雷德·哈钦森癌症中心)🌐USA

Associate Member, Basic Sciences Division; Associate Member, Public Health Sciences Division基础科学部副研究员；公共卫生科学部副研究员

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Computational and experimental leader in understanding how spliceosome mutations in SF3B1, U2AF1, and SRSF2 alter RNA processing in myeloid cancers. Combines machine learning with genomics to decode splicing-driven cancer mechanisms.

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🧪Research Fields 研究领域

Cancer RNA Splicing癌症RNA剪接
SF3B1 and U2AF1 MutationsSF3B1和U2AF1突变
SRSF2 SplicingSRSF2剪接
Myeloid Cancer Transcriptomics髓系癌症转录组学
Computational RNA Biology计算RNA生物学

🎓Key Contributions 主要贡献

SF3B1 Mutation Splicing Mechanism

Elucidated the precise molecular mechanism by which mutant SF3B1 alters branch point recognition to produce cryptic 3' splice sites genome-wide in cancer cells.

Computational Splicing Cancer Tools

Developed bioinformatics frameworks for detecting and quantifying aberrant splicing events in cancer transcriptomes, widely adopted in the field.

Representative Works 代表性著作

[1]

Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains

Genome Research (2021)

Demonstrated intron retention as a widespread RNA processing defect in neurological disease with cancer parallels.

[2]

Mutant U2AF1 expression alters mRNA splicing in mouse hematopoietic cells

PNAS (2019)

Mouse model demonstrating how U2AF1 mutations drive aberrant splicing in hematopoietic malignancies.

[3]

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

Nature Cancer (2022)

Identified synthetic lethality between SF3B1 mutations and PARP inhibitors in cancer.

🏆Awards & Recognition 奖项与荣誉

🏆NIH Director's New Innovator Award
🏆Damon Runyon Cancer Research Foundation Scholar
🏆American Society of Hematology Scholar

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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