Riccardo Dalla-Favera
里卡多·达拉-法韦拉
MD
Percy and Joanne Uris Professor of Clinical Medicine; Director, Institute for Cancer Genetics临床医学教授兼癌症遗传学研究所所长
👥Biography 个人简介
Riccardo Dalla-Favera is a molecular oncologist who discovered the BCL6 oncogene and elucidated its role in germinal center B-cell development and lymphomagenesis. His laboratory defined key genetic lesions in DLBCL and Burkitt lymphoma, transforming understanding of B-cell malignancy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BCL6 Oncogene Discovery
Discovered BCL6 as the most commonly rearranged oncogene in DLBCL and defined its role as a master regulator of germinal center B-cell biology.
MYC and Burkitt Lymphoma
Characterized chromosomal translocations activating MYC in Burkitt lymphoma, providing foundational insights into oncogene activation mechanisms.
DLBCL Genetic Landscape
Mapped somatic mutations and structural variants in DLBCL through large-scale genomic studies informing subclassification and therapeutic targeting.
Representative Works 代表性著作
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
Cell (1995)
Defined BCL6 as a transcriptional repressor essential for germinal center formation and lymphomagenesis.
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Nature (2009)
Comprehensive mutation analysis identifying recurrent genetic lesions activating NF-kB in DLBCL.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Elaine Jaffe
National Cancer Institute, NIH
Nancy Lee Harris
Massachusetts General Hospital, Harvard Medical School
Philippe Gaulard
Henri Mondor Hospital, Paris Est University
Andreas Rosenwald
University of Würzburg
关注 里卡多·达拉-法韦拉 的研究动态
Follow Riccardo Dalla-Favera's research updates
留下邮箱，当我们发布与 Riccardo Dalla-Favera（Columbia University Irving Medical Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment