René Bernards
勒内·伯纳兹
PhD
Professor of Molecular Carcinogenesis; Head, Division of Molecular Carcinogenesis分子致癌学教授；分子致癌学部门主任
👥Biography 个人简介
René Bernards is a leading authority on cancer drug resistance and genetic functional screens at the Netherlands Cancer Institute. His laboratory pioneered large-scale RNAi and CRISPR screens to identify mechanisms of resistance to targeted therapies, particularly in BRAF-mutant melanoma and colorectal cancer, informing combination therapy strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Genetic Screens for Drug Resistance
Pioneered genome-wide RNAi loss-of-function screens to identify genes whose suppression confers resistance or sensitivity to targeted cancer therapies, including BRAF and MEK inhibitors.
BRAF Inhibitor Resistance Mechanisms
Identified key mechanisms of intrinsic and acquired resistance to BRAF inhibitors in melanoma and colorectal cancer, including EGFR feedback activation and KRAS amplification.
Oncogene Addiction and Synthetic Lethality
Developed functional approaches to exploit cancer-specific vulnerabilities, identifying synthetic lethal interactions that can be targeted in RAS-driven and other cancers.
Representative Works 代表性著作
An shRNA barcode screen provides insight into cancer cell vulnerability and oncogene addiction
Nature Medicine (2006)
Demonstrated the power of shRNA pooled screens for identifying oncogene dependencies and predicting sensitivity to targeted cancer therapies.
Melanoma: Escaping the trap
Nature (2012)
Described mechanisms by which BRAF-mutant melanoma cells escape BRAF inhibition through ERK reactivation and vertical pathway bypass.
A genetic screen identifies TCF3 as a suppressor of EMT and the invasion program
Nature Cell Biology (2014)
Identified TCF3 as a key transcriptional suppressor of EMT, providing new mechanistic insights into epithelial plasticity in cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Navdeep Chandel
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