Ralph DeBerardinis
拉尔夫·德贝拉迪尼斯
MD, PhD
Chief, Division of Pediatric Genetics and Metabolism; Professor, Children's Medical Center Research Institute儿科遗传与代谢科主任；儿童医疗中心研究所教授
👥Biography 个人简介
Ralph DeBerardinis is a physician-scientist renowned for applying isotope tracing and metabolic flux analysis to study how tumors metabolize nutrients in living patients. His work revealed that tumor metabolism in vivo often differs markedly from findings in cell culture, redefining cancer metabolism research.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
In Vivo Tumor Metabolism
Pioneered stable isotope tracing in cancer patients to measure real-time metabolic fluxes within tumors, revealing that in vivo metabolism often diverges from cell culture models.
Glutamine as Universal Cancer Fuel
Established glutamine as a critical carbon and nitrogen source for tumor biosynthesis through anaplerosis, providing a metabolic rationale for anti-glutamine cancer therapies.
Metabolic Heterogeneity in Tumors
Demonstrated that metabolic heterogeneity within tumors reflects both genetic diversity and microenvironmental influences, with implications for therapy resistance.
Representative Works 代表性著作
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Journal of Clinical Investigation (2012)
Landmark review establishing glutamine metabolism as a central feature of cancer biology with direct therapeutic relevance.
Stable isotope tracing of human tumors reveals altered preferences for metabolic fates of glucose and glutamine
Nature Medicine (2019)
First systematic isotope tracing in human patients, revealing preferred metabolic pathways of common cancers in vivo.
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
PNAS (2007)
Demonstrated that cancer cells consume glutamine far in excess of biosynthetic needs, indicating glutamine as a major energy source.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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