Ralph J. DeBerardinis
拉尔夫·德贝拉迪尼斯
MD, PhD
Professor and Chief, Division of Pediatric Genetics; Investigator, Howard Hughes Medical Institute儿科遗传学主任；霍华德·休斯医学研究所研究员
👥Biography 个人简介
Ralph DeBerardinis, MD, PhD is an HHMI Investigator at UT Southwestern and a world leader in cancer metabolomics. His laboratory pioneered stable isotope tracing to map metabolic fluxes in tumors in vivo, revealing how cancer cells use glutamine and other nutrients in living tissue, findings that have reshaped target identification in cancer metabolism.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
In Vivo Isotope Tracing
Developed and applied in vivo 13C isotope tracing in patients and animal models to directly measure TCA cycle and biosynthetic fluxes in human tumors, moving the field from cell culture to physiological context.
Glutamine and Asparagine Metabolism
Demonstrated that glutamine supports TCA cycle anaplerosis and that asparagine acts as an exchange factor enabling amino acid uptake, revealing new metabolic dependencies in cancer.
Representative Works 代表性著作
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Journal of Clinical Investigation (2012)
Comprehensive review of glutamine metabolism in cancer biology, widely cited as a foundational reference in the field.
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
Molecular Cell (2016)
Resolved compartment-specific NADPH production, revealing how cancer cells maintain redox balance during proliferation.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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