Raghu Kalluri
拉古·卡卢里
MD, PhD
Chair and Professor, Department of Cancer Biology癌症生物学系主任兼教授
👥Biography 个人简介
Raghu Kalluri is a world leader in tumor stroma biology and extracellular vesicle research at MD Anderson Cancer Center. His laboratory pioneered the study of cancer-associated fibroblasts, tumor exosomes as intercellular communication mediators, and EMT in cancer progression. His work has yielded critical insights into pancreatic cancer biology and liquid biopsy development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Exosome Biology in Cancer
Demonstrated that tumor-derived exosomes prepare pre-metastatic niches, deliver oncogenic cargo, and serve as liquid biopsy biomarkers, including glypican-1 as a pancreatic cancer marker.
Cancer-Associated Fibroblasts
Elucidated the heterogeneous roles of CAFs in tumor promotion versus suppression, revealing that not all stroma is pro-tumorigenic and informing stromal-targeting strategies.
EMT in Metastasis
Conducted landmark genetic studies showing EMT is dispensable for metastatic dissemination in pancreatic cancer but contributes to chemotherapy resistance.
Representative Works 代表性著作
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Nature (2015)
Identified glypican-1-positive exosomes as highly sensitive and specific liquid biopsy biomarkers for early-stage pancreatic cancer detection.
EMT: 2016
Cell (2016)
Comprehensive state-of-the-field review redefining EMT as a spectrum of partial states with context-dependent roles in invasion, metastasis, and drug resistance.
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer
Cancer Cell (2012)
Revealed that CAF depletion paradoxically accelerates pancreatic cancer, cautioning against indiscriminate anti-stromal therapies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Weill Cornell Medicine
Craig Thompson
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Matthew Vander Heiden
Massachusetts Institute of Technology
Navdeep Chandel
Northwestern University Feinberg School of Medicine
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