Pieter Sonneveld
彼得·索内维尔德
MD, PhD
Professor of Hematology & Head, Department of Hematology血液学教授暨血液科主任
👥Biography 个人简介
Pieter Sonneveld leads the hematology department at Erasmus MC and is a founding figure in European myeloma research. He was a principal investigator on the POLLUX and CASTOR trials establishing daratumumab in relapsed myeloma and has authored pivotal work on high-risk cytogenetics and drug resistance mechanisms.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
POLLUX and CASTOR Trials – Daratumumab in Relapsed Myeloma
Served as a principal investigator on the POLLUX (D-Rd) and CASTOR (D-Vd) phase III trials, establishing daratumumab-based regimens as standard of care in relapsed/refractory myeloma across all cytogenetic risk groups.
Genetic Risk Stratification in Myeloma
Developed and validated EMN (European Myeloma Network) risk stratification models based on FISH and gene expression profiling, enabling risk-adapted treatment allocation and clinical trial stratification for high-risk myeloma.
Drug Resistance Mechanisms
Led HOVON-group translational studies identifying mechanisms of proteasome inhibitor resistance in myeloma, including mutations in PSMB5 and alterations in the ubiquitin-proteasome pathway, guiding rational combination strategies.
Representative Works 代表性著作
Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma (POLLUX)
New England Journal of Medicine (2016)
Phase III trial showing D-Rd doubled PFS compared to Rd in relapsed/refractory myeloma, establishing a new standard of care.
Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma (CASTOR)
New England Journal of Medicine (2016)
Phase III trial demonstrating D-Vd superiority over Vd in relapsed/refractory myeloma, including patients with 1 prior line of therapy.
High-Risk Cytogenetics and Treatment Outcome in Multiple Myeloma: EMN Analysis
Leukemia (2022)
Large EMN registry analysis defining the prognostic impact of high-risk cytogenetic abnormalities and identifying subgroups requiring treatment intensification.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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