Phillip A. Sharp
菲利普·夏普
PhD
Institute Professor, Koch Institute for Integrative Cancer Research科赫综合癌症研究所研究所教授
👥Biography 个人简介
Nobel Laureate co-discoverer of RNA splicing. Continued as a leader in cancer RNA biology, elucidating super-enhancer-associated lncRNAs in cancer transcription, and founding key cancer RNA research programs. Nobel Prize in Physiology or Medicine 1993.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Discovery of RNA Splicing
Co-discovered RNA splicing — the process by which introns are removed from pre-mRNA — a fundamental mechanism whose dysregulation underlies numerous cancers.
Super-Enhancer RNA in Cancer
Identified that cancer cells use super-enhancers to drive expression of oncogenic transcription factors and associated non-coding RNAs that maintain cancer cell identity.
Representative Works 代表性著作
Spliced segments at the 5' terminus of adenovirus 2 late mRNA
PNAS (1977)
Nobel Prize-winning discovery demonstrating RNA splicing, fundamentally altering understanding of eukaryotic gene expression.
Transcriptional super-enhancers connected to cell identity and disease
Cell (2013)
Defined super-enhancers as unusually large regulatory elements driving oncogene expression in cancer cells.
Phase separation of signaling molecules promotes T cell receptor signal transduction
Science (2016)
Contributed to understanding of RNA-containing phase-separated condensates relevant to gene regulation in cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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