Philippe Moreau
菲利普·莫罗
MD
Professor of Hematology & Head of Hematology Department血液学教授暨血液科主任
👥Biography 个人简介
Philippe Moreau is France's foremost myeloma expert and a global leader in frontline transplant-eligible treatment trials. He led the CASSIOPEIA trial establishing daratumumab-VTd as standard induction/consolidation and the IFM group's landmark studies redefining transplant strategies in myeloma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CASSIOPEIA Trial – Daratumumab-VTd Induction
Led the IFM/HOVON CASSIOPEIA phase III trial demonstrating that adding daratumumab to VTd induction and consolidation significantly deepens response and improves PFS in transplant-eligible newly diagnosed myeloma.
Transplant Strategy Optimization
Co-led the IFM 2009 trial comparing early versus delayed transplant with lenalidomide-based therapy, providing definitive data supporting upfront ASCT as the standard of care in eligible patients.
Smoldering Myeloma and IMWG Diagnostic Criteria
Contributed to IMWG updates revising the definition of active myeloma requiring treatment, incorporating new biomarker-defined criteria and enabling earlier therapeutic intervention in ultra-high-risk patients.
Representative Works 代表性著作
Daratumumab, Thalidomide, and Dexamethasone Versus VTd in Myeloma (CASSIOPEIA)
Lancet (2019)
Phase III trial showing D-VTd improved stringent CR and PFS in transplant-eligible newly diagnosed myeloma, leading to European approval.
Lenalidomide, Bortezomib, and Dexamethasone with Transplant Versus without Transplant (IFM 2009)
New England Journal of Medicine (2017)
Definitive trial demonstrating upfront ASCT after RVd induction achieves superior PFS compared to delayed transplant strategy.
Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Myeloma (GMMG-HD7)
Lancet Haematology (2023)
Phase III trial demonstrating Isa-KRd quadruplet induction improves MRD-negativity rates versus KRd in transplant-eligible myeloma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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