Peter Campbell

Peter Campbell is Head of the Cancer, Ageing and Somatic Mutation (CASM) programme at the Wellcome Sanger Institute. He leads one of the world's most productive cancer genome groups, which has characterized the genomic landscapes of dozens of cancer types at unprecedented scale and depth. Campbell's group made landmark contributions to the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium — the largest whole-genome cancer study ever conducted, analyzing 2,658 cancer genomes across 38 cancer types. His work revealed the timing of mutations during cancer development, showing most driver mutations accumulate years to decades before diagnosis. His laboratory developed the mathematical framework for identifying mutational signatures — patterns of mutations caused by specific DNA damage processes (e.g., APOBEC, BRCA deficiency, tobacco) — which has transformed understanding of cancer causes and opened new diagnostic and therapeutic opportunities.

Peter Campbell 是维康桑格研究所癌症、衰老与体细胞突变（CASM）计划的负责人。他领导着世界上最多产的癌症基因组研究组之一，以前所未有的规模和深度表征了数十种癌症类型的基因组全景。 Campbell的团队为泛癌症全基因组分析（PCAWG）联盟做出了里程碑式贡献——有史以来规模最大的全基因组癌症研究，分析了38种癌症类型的2,658个癌症基因组。他的工作揭示了癌症发展过程中突变的时序，表明大多数驱动突变在诊断前数年至数十年就已积累。