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research / researchCancer Nanotechnology

Paula T. Hammond

宝拉·哈蒙德

PhD

🏢Massachusetts Institute of Technology, Koch Institute(麻省理工学院科赫研究所)🌐USA

Institute Professor; Head, Department of Chemical Engineering学院教授；化学工程系主任

110
h-index
2
Key Papers
5
Awards
2
Key Contributions

👥Biography 个人简介

Pioneer of layer-by-layer (LbL) nanoparticle assembly for combination cancer therapy. MIT Institute Professor and former MIT Chemical Engineering Head. Develops precisely engineered nanoparticle surfaces enabling sequential drug and siRNA delivery to solid tumors including ovarian and breast cancer.

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🧪Research Fields 研究领域

Layer-by-Layer Nanoparticles层层自组装纳米粒子
Cancer Combination Therapy癌症联合治疗
siRNA-Drug Co-deliverysiRNA-药物共递送
Nanoparticle Surface Engineering纳米粒子表面工程
Ovarian Cancer Nanomedicine卵巢癌纳米药物

🎓Key Contributions 主要贡献

Layer-by-Layer Nanoparticle Assembly

Pioneered LbL self-assembly technique to coat nanoparticles with multiple drug-loaded polyelectrolyte layers, enabling programmable sequential release of siRNA and chemotherapy in tumor models.

Combination siRNA-Chemotherapy Nanoparticles

Developed LbL nanoparticles simultaneously delivering siRNA targeting drug resistance genes and chemotherapeutic agents, overcoming multidrug resistance in ovarian cancer models.

Representative Works 代表性著作

[1]

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA

ACS Nano (2012)

Demonstrated LbL nanoparticles co-delivering doxorubicin and siRNA to overcome MDR1-mediated resistance in ovarian cancer.

[2]

Self-Assembled RNA-Triple-Helix Hydrogel Scaffold

Nature Materials (2015)

Engineered RNA-based hydrogel nanostructures for sustained anti-cancer cytokine delivery in tumor microenvironment.

🏆Awards & Recognition 奖项与荣誉

🏆National Medal of Science (2021)
🏆American Institute of Chemical Engineers Wilhelm Award
🏆ACS Award in Applied Polymer Science
🏆Materials Research Society Medal
🏆National Academy of Engineering Member

📄Data Sources 数据来源

InstitutionProfile

Last updated: 2026-01-15 | All information from publicly available academic sources

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