research / researchCancer Nanotechnology

Patrick Couvreur

帕特里克·库弗勒

PhD, PharmD

🏢Paris-Saclay University (Institut Galien Paris-Saclay)(巴黎-萨克雷大学（巴黎-萨克雷加利安研究所）)🌐France

Professor Emeritus; Member, French Academy of Sciences荣休教授；法国科学院院士

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

European pioneer of nanomedicine and one of the world's most cited pharmaceutical scientists. Invented squalenoylation (conjugating drugs to squalene for self-assembling nanoparticles). Developed first biodegradable polymer nanoparticles for cancer drug delivery in the 1970s. French Academy of Sciences member.

🧪Research Fields 研究领域

Nanomedicine Foundations纳米药物基础

Squalenoylation角鲨烯化修饰

Polymer Nanoparticles聚合物纳米粒子

Anticancer Nanocarriers抗癌纳米载体

Biodegradable Nanoparticles可降解纳米粒子

🎓Key Contributions 主要贡献

Squalenoylation: Self-Assembling Drug Nanoparticles

Invented the squalenoylation concept, conjugating anticancer drugs such as gemcitabine to squalene lipids enabling spontaneous nanoparticle self-assembly without excipients, improving tumor delivery and reducing toxicity.

Biodegradable Polymer Nanoparticles for Cancer

Pioneered PACA (polyalkylcyanoacrylate) biodegradable nanoparticles in the 1970s–80s, establishing foundational principles of polymer nanoparticle drug encapsulation for oncology applications.

Representative Works 代表性著作

[1]

Squalenoyl Gemcitabine Nanoparticles for Pancreatic Cancer

Nature Nanotechnology (2006)

Demonstrated squalene-gemcitabine nanoparticles self-assembling from drug-lipid conjugates with superior anticancer efficacy vs. free gemcitabine in pancreatic cancer models.

[2]

Nanoparticles in Cancer Therapy and Diagnosis

Advanced Drug Delivery Reviews (2012)

Comprehensive review of nanoparticle platforms in oncology, widely regarded as a definitive reference in nanomedicine.

🏆Awards & Recognition 奖项与荣誉

🏆Galien Prize (France)

🏆European Inventor Award (2013)

🏆Controlled Release Society Founders Award

🏆IUPAC Distinguished Award for Novel Materials

🏆Chevalier de la Légion d'Honneur

📄Data Sources 数据来源

Institution Profile

Last updated: 2026-01-15 | All information from publicly available academic sources

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