Pancras C.W. Hogendoorn
潘克拉斯·霍根多恩
MD, PhD
Professor and Chair, Department of Pathology; Head, Bone Tumor Reference Center病理学系教授兼主任；骨肿瘤参考中心负责人
👥Biography 个人简介
Pancras Hogendoorn is a world authority in bone tumor pathology and genomics at Leiden University Medical Center, where he directs one of Europe's leading bone tumor reference centers. He chaired the WHO Classification of Tumours of Soft Tissue and Bone (4th and 5th editions), the definitive global reference for tumor classification. His research encompasses osteosarcoma genomics, chondrosarcoma IDH mutations, and the molecular basis of bone tumor diversity, with major contributions to the understanding of tumor heterogeneity and clonal evolution.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
WHO Classification of Bone and Soft Tissue Tumors
Served as editor-in-chief for the WHO Classification of Tumours of Soft Tissue and Bone (4th edition, 2013; 5th edition, 2020), establishing internationally recognized diagnostic criteria, nomenclature, and molecular definitions for all bone and soft tissue tumor entities.
Osteosarcoma Genomic Instability and Heterogeneity
Led genomic studies characterizing the complex, chromothripsis-driven chromosomal instability of osteosarcoma, demonstrating extreme intra-tumor heterogeneity and identifying recurrently mutated pathways including TP53, RB1, and DLG2.
IDH Mutations in Chondrosarcoma
Contributed to the characterization of IDH1/IDH2 mutations in enchondroma-associated and central chondrosarcoma, establishing the molecular basis for the Ollier disease/Maffucci syndrome spectrum and potential therapeutic targeting.
Representative Works 代表性著作
WHO Classification of Tumours of Soft Tissue and Bone (5th Edition)
IARC Press / World Health Organization (2020)
Authoritative global classification reference for bone and soft tissue tumors, editor-in-chief.
The Genomic Landscape of Osteosarcoma
Cancer Discovery (2014)
Comprehensive genomic analysis revealing chromothripsis as a dominant mutational process in osteosarcoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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