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research / researchradiogenomics, imaging-genomics, TCIA, multimodal AI, radiology AI, cancer imaging informaticsBispecific T-cell Engager Pioneer

Olivier Gevaert

奥利维尔·热瓦尔

PhD

🏢Stanford University(斯坦福大学)🌐USA

Associate Professor, Department of Medicine and Department of Biomedical Data Science, Stanford University; Director, Stanford Center for Biomedical Informatics Research (BMIR) Imaging Informatics Program斯坦福大学医学与生物医学数据科学系副教授;斯坦福生物医学信息学研究中心影像信息学项目主任

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Key Contributions

👥Biography 个人简介

Olivier Gevaert, PhD is Associate Professor in the Department of Medicine and Department of Biomedical Data Science at Stanford University, where he directs the imaging informatics program within the Stanford Center for Biomedical Informatics Research (BMIR). Dr. Gevaert is a pioneer in radiogenomics — the field integrating radiological imaging features with genomic and molecular profiles to discover imaging biomarkers that reflect tumor biology. His laboratory develops machine learning models that extract quantitative imaging features (radiomic and deep learning features) from CT, MRI, and PET scans and link them to gene expression signatures, copy number alterations, somatic mutations, and clinical outcomes, enabling non-invasive molecular tumor characterization from standard-of-care imaging. Dr. Gevaert has been a major contributor to The Cancer Imaging Archive (TCIA), the NCI-sponsored public imaging data repository, where he has led data curation and analysis efforts for multiple cancer imaging-omics datasets that are now widely used by the computational oncology community. His group has published multimodal AI frameworks for glioblastoma, lung, breast, and ovarian cancer, demonstrating that imaging-genomics integration improves prognostic accuracy beyond either modality alone. He has also contributed methodological advances in transfer learning, graph neural networks, and interpretable AI for radiology.

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🧪Research Fields 研究领域

Radiogenomics — Linking Radiological Imaging Features to Genomic and Molecular Profiles放射基因组学——将放射成像特征与基因组学和分子图谱联系起来
Cancer Imaging Informatics — TCIA (The Cancer Imaging Archive) and Large-Scale Imaging-Omics Datasets癌症影像信息学——TCIA(癌症影像档案)和大规模成像组学数据集
Deep Learning for Radiology — CT, MRI, and PET-Based Cancer Detection and Characterization放射学深度学习——基于CT、MRI和PET的癌症检测与表征
Multimodal Data Integration — Imaging, Genomics, Pathology, and Clinical Record Fusion多模态数据整合——影像、基因组学、病理和临床记录融合
Precision Radiology — AI-Based Imaging Biomarkers for Treatment Response and Prognosis精准放射学——用于治疗反应和预后的AI成像生物标志物

🎓Key Contributions 主要贡献

Radiogenomics — Linking CT/MRI Imaging Features to Genomic Profiles

Established radiogenomics as a systematic computational discipline by developing methodological frameworks to extract quantitative radiomic and deep learning features from cancer imaging datasets and associate them with multi-omics molecular profiles including gene expression, CNV, somatic mutations, and methylation. Published landmark radiogenomics studies in radiology and cancer genomics journals linking CT imaging features to EGFR, KRAS, and ALK mutation status in lung cancer; MGMT promoter methylation in glioblastoma; and molecular subtypes in breast cancer, providing non-invasive surrogates for tumor molecular characterization.

TCIA — Cancer Imaging Archive Curation and Imaging-Omics Integration

Led major contributions to The Cancer Imaging Archive (TCIA), the NCI-funded public repository of cancer imaging datasets, by creating, curating, and publishing matched imaging-genomics collections that pair radiology data with TCGA genomic profiles. These datasets have become foundational resources for computational radiology research, enabling hundreds of downstream radiogenomics and AI radiology studies. Developed standardized pipelines for imaging feature extraction, harmonization across scanners, and multi-site imaging-omics data integration.

Multimodal AI for Glioblastoma — Imaging-Genomics-Clinical Integration

Developed and validated multimodal deep learning models for glioblastoma (GBM) that integrate MRI imaging features, gene expression profiles, and clinical data for overall survival prediction and molecular subtype classification. Demonstrated that imaging-genomics fusion models substantially outperform unimodal radiology or genomics models for GBM prognosis, and identified imaging correlates of IDH mutation, EGFR amplification, and MGMT methylation status from pre-operative MRI sequences, enabling non-invasive preoperative molecular risk stratification.

Graph Neural Networks for Spatial Omics and Imaging Analysis

Introduced graph neural network (GNN) architectures for cancer imaging and spatial omics analysis, modeling spatial relationships between imaging regions, tissue compartments, and single-cell spatial gene expression profiles as graph structures. Published methodological innovations in graph-based survival prediction from CT imaging and spatial transcriptomics, demonstrating that modeling spatial topology of tumor microenvironments through GNNs captures biologically meaningful organization patterns that improve AI prognosis models beyond pixel-based or patch-based approaches.

Representative Works 代表性著作

[1]

Predicting the Prognosis of Glioblastoma: An MRI-Based Radiogenomics Approach

Radiology (2014)

Early landmark radiogenomics study integrating MRI features with gene expression profiles to predict GBM prognosis, establishing imaging-genomics integration for neuro-oncology AI.

[2]

Association Between Radiology Imaging Features and Underlying Genomic Patterns in Patients with Invasive Breast Cancer

Radiology (2015)

Radiogenomics analysis linking mammographic and MRI imaging features to TCGA breast cancer molecular subtypes and gene expression signatures.

[3]

Multimodal Data Fusion in High-Dimensional Heterogeneous Datasets via Generative Models

Nature Communications (2021)

Generative model framework for multimodal cancer data integration across imaging, genomics, and clinical modalities with missing data handling for large heterogeneous patient cohorts.

[4]

Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Affected by Stroma

NPJ Precision Oncology (2019)

Identification of imaging-based PDAC subtypes associated with stromal biology and clinical outcomes, linking CT morphology to transcriptomic subtypes relevant to treatment selection.

🏆Awards & Recognition 奖项与荣誉

🏆NIH R01 Outstanding New Investigator Award
🏆Stanford Bio-X Interdisciplinary Initiative Award
🏆RSNA Honored Educator Award in Imaging Informatics
🏆ISMRM Best Paper Award in Machine Learning
🏆NCI Cancer Systems Biology Consortium Young Investigator Award

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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