Ola Landgren
奥拉·兰德格伦
MD, PhD
Chief of Myeloma Service & Professor of Medicine骨髓瘤科主任暨医学教授
👥Biography 个人简介
Ola Landgren leads the Myeloma Service at Sylvester/UM Miami and is a pioneer in MRD-guided therapy and precursor disease biology. A founding contributor to IMWG MRD consensus criteria, he has transformed how treatment depth is measured in myeloma clinical trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MRD as Clinical Trial Endpoint
Championed minimal residual disease negativity as a surrogate endpoint in myeloma trials, co-authoring IMWG consensus guidelines that are now incorporated in FDA trial design recommendations.
MGUS and Smoldering Myeloma Biology
Conducted population-based studies clarifying the epidemiology and genomic drivers of progression from MGUS through smoldering myeloma to active disease, informing early intervention strategies.
Next-Generation Flow and Sequencing for MRD
Developed and validated next-generation sequencing-based MRD assays achieving 10⁻⁶ sensitivity, establishing the technical framework adopted by major academic centers worldwide.
Representative Works 代表性著作
MRD Negativity as a Surrogate Endpoint in Multiple Myeloma
Leukemia (2021)
Meta-analysis validating MRD negativity as a strong prognostic surrogate for PFS and OS across myeloma treatment lines.
Prevalence of Monoclonal Gammopathy of Undetermined Significance
New England Journal of Medicine (2006)
Landmark population study defining MGUS prevalence and risk factors in >21,000 individuals, establishing screening frameworks.
Carfilzomib, Lenalidomide, Dexamethasone and MRD in Newly Diagnosed Myeloma
Blood Cancer Journal (2023)
Prospective trial demonstrating high MRD-negativity rates with KRd induction in transplant-eligible newly diagnosed myeloma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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