Nir Hacohen
尼尔·哈科恩
PhD
Director, Center for Cancer Immunology; Professor, Harvard Medical School癌症免疫学中心主任；哈佛医学院教授
👥Biography 个人简介
Nir Hacohen pioneers single-cell and systems approaches to cancer immunology at the Broad Institute and MGH. His lab maps immune cell states in tumors, identifies neoantigens for personalized vaccines, and decodes immunotherapy response mechanisms through large-scale genomic analyses.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Tumor Immune Atlas
Generated comprehensive single-cell RNA-seq atlases of tumor-infiltrating immune cells across cancer types, revealing cell states associated with immunotherapy response and resistance.
Personalized Cancer Vaccines
Pioneered neoantigen-based personalized cancer vaccine design, leading clinical trials demonstrating immunogenicity and durable responses in melanoma patients.
Cancer Immunotherapy Genomics
Identified genomic determinants of immunotherapy response including tumor mutational burden, neoantigen load and immune checkpoint expression patterns.
Representative Works 代表性著作
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
Nature (2017)
Landmark clinical study demonstrating personalized neoantigen vaccines can induce durable anti-tumor T cell responses in melanoma.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Science (2017)
Defined human immune cell taxonomy using single-cell RNA sequencing with broad implications for cancer immunology.
Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing
Cell (2017)
Comprehensive single-cell characterization of T cell diversity and dysfunction in hepatocellular carcinoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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