Miriam Merad
米里亚姆·梅拉德
MD, PhD
Director, Marc and Jennifer Lipschultz Precision Immunology Institute; Professor of Immunology and Oncological Sciences精准免疫学研究所所长；免疫学与肿瘤科学教授
👥Biography 个人简介
Director of the Precision Immunology Institute at Mount Sinai and global leader in dendritic cell and tissue-resident macrophage biology. Merad's landmark single-cell atlases and translational studies have reshaped understanding of myeloid cell diversity in cancer, identifying novel subsets governing immunotherapy response.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Macrophage Tissue Residence & Self-Renewal
Established that tissue-resident macrophages self-renew independently of bone marrow progenitors in each organ, with profound implications for how residency-derived macrophage identity shapes tumor immune surveillance.
Myeloid Cell scRNA-seq Atlases in Cancer
Led landmark single-cell atlases of human cancer immune microenvironments, identifying dendritic cell and macrophage states predictive of immunotherapy resistance and clinical outcomes across multiple solid tumor types.
Representative Works 代表性著作
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
Immunity (2013)
Established the embryonic origin and self-renewal capacity of tissue-resident macrophages, fundamentally revising macrophage biology relevant to tumor settings.
A dendritic cell subset that potently activates T cells in tumors
Science (2019)
Identified a rare tumor-infiltrating dendritic cell subset critical for cross-presenting tumor antigens and driving anti-tumor T cell responses linked to checkpoint blockade efficacy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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