Mikael J. Pittet
米卡埃尔·皮泰
PhD
Professor, Department of Pathology and Immunology病理学与免疫学系教授
👥Biography 个人简介
Mikael Pittet is a leading expert on tumor-infiltrating immune cells and myeloid cell biology at the University of Geneva. His laboratory uses advanced intravital imaging and single-cell profiling to dissect how macrophages, monocytes, and neutrophils regulate tumor progression and responses to immunotherapy, revealing profound heterogeneity in the tumor immune microenvironment.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Myeloid Cell Heterogeneity in Tumors
Used single-cell sequencing and intravital imaging to reveal the diverse origins, phenotypes, and functions of macrophages and monocytes within solid tumors.
Macrophage Regulation of Immunotherapy Response
Identified how tumor-associated macrophages modulate T cell activity and checkpoint immunotherapy outcomes, pinpointing myeloid cells as key determinants of anti-tumor immunity.
Intravital Imaging of Tumor Immunity
Developed multiphoton intravital microscopy approaches to track immune cell behavior in living tumors, capturing dynamic interactions between cancer and immune cells in real time.
Representative Works 代表性著作
Tumor-associated macrophages: from mechanisms to therapy
Immunity (2014)
Comprehensive review of macrophage diversity in tumors and how targeting TAMs can potentiate cancer immunotherapy.
Phenotypic states of macrophages in tumors
Science Immunology (2021)
Used single-cell profiling to resolve macrophage phenotypic diversity in mouse and human tumors and map their functional states in the TME.
Fate mapping of CD11b+ cells defines a novel myeloid subset in tumors
Journal of Experimental Medicine (2010)
Traced monocyte-to-macrophage differentiation in tumors using fate mapping, establishing the dynamic nature of myeloid cell recruitment and polarization.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Matthew Vander Heiden
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Navdeep Chandel
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