research / researchTumor Microenvironment

Mikael J. Pittet

米凯尔·皮特

PhD

🏢Massachusetts General Hospital / Harvard Medical School(麻省总医院/哈佛医学院)🌐USA

Professor of Immunology; Director, Center for Systems Biology免疫学教授；系统生物学中心主任

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

Leader in single-cell and intravital imaging approaches to map tumor immune landscapes at MGH/Harvard. Pittet's high-resolution atlases of tumor macrophage and cDC1 dendritic cell states have transformed understanding of why patients respond or resist to checkpoint immunotherapy.

🧪Research Fields 研究领域

Tumor Macrophage Single-Cell Atlas肿瘤巨噬细胞单细胞图谱

Immunotherapy Response Biomarkers免疫治疗应答生物标志物

cDC1 Dendritic CellscDC1树突状细胞

Intravital Imaging活体成像

scRNA-seq TME单细胞转录组TME

🎓Key Contributions 主要贡献

Single-Cell Tumor Macrophage Atlas

Constructed high-resolution scRNA-seq atlases of tumor-infiltrating macrophages across cancer types, revealing conserved immunosuppressive states and rare cytotoxic subsets that predict checkpoint immunotherapy failure or response.

cDC1-Mediated Anti-Tumor T Cell Priming

Established that intratumoral cDC1 dendritic cells are rate-limiting for CD8 T cell priming and immunotherapy efficacy, identifying BATF3 and XCR1 as key markers of this therapeutic pivot cell population.

Representative Works 代表性著作

[1]

A single-cell atlas of the tumor immune microenvironment reveals treatment-related changes

Cell (2022)

Pan-cancer single-cell atlas delineating macrophage, DC, and T cell states that govern immunotherapy outcomes and evolve under treatment pressure across solid tumor types.

[2]

Macrophage ontogeny shapes their tissue residency and anti-tumor function

Immunity (2020)

Demonstrated developmental origin determines macrophage functional programs in tumors, with implications for predicting TAM behavior and designing TME-targeted therapies.

🏆Awards & Recognition 奖项与荣誉

🏆ERC Consolidator Grant

🏆NIH Outstanding Investigator Award

🏆Cancer Research Institute William B. Coley Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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