Michel C. Nussenzweig
米歇尔·努森茨维格
MD, PhD
Zanvil A. Cohn and Ralph M. Steinman Professor; Head, Laboratory of Molecular Immunology分子免疫学实验室主任，Steinman讲席教授
👥Biography 个人简介
Michel Nussenzweig is a Howard Hughes Medical Institute Investigator and close collaborator of Nobel laureate Ralph Steinman at Rockefeller University. His laboratory has made foundational contributions to understanding dendritic cell development, antigen presentation, and how DCs orchestrate adaptive immune responses against cancer. His work on DC-targeted cancer vaccines and broadly neutralizing antibodies has shaped modern tumor immunology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Dendritic Cell Development
Defined key transcriptional programs governing plasmacytoid and conventional dendritic cell differentiation and function in anti-tumor immunity.
DC-Targeted Cancer Vaccines
Pioneered antigen delivery strategies targeting DEC-205 receptor on dendritic cells to enhance cross-presentation and CD8+ T cell priming against tumors.
Antibody Engineering
Developed broadly neutralizing antibody platforms applicable to cancer immunotherapy and HIV, illuminating germinal center dynamics driven by dendritic cells.
Representative Works 代表性著作
Targeting antigen to the CD205 receptor of human dendritic cells activates both innate and adaptive immunity
Nature Medicine (2014)
Demonstrated that DEC-205-targeted antigen delivery robustly primes tumor-specific CD8+ T cells in human clinical settings.
Dendritic cell subsets and their role in cancer immunosurveillance
Immunity (2021)
Comprehensive review of cDC1 and cDC2 functional specialization in cross-presentation and CD4+ T helper licensing within the tumor microenvironment.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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