Upcoming · By Invitation

International Translational Oncology Exchange

Boston · May 13, 202614:00 – 16:00 ET
Learn more →
←Back to Expert Scholars
research / researchimmunometabolism and tumor immune evasion

Lydia Lynch

莉迪亚·林奇

PhD

🏢Harvard Medical School / Brigham and Women's Hospital(哈佛医学院/布列根妇女医院)🌐Ireland/USA

Associate Professor of Medicine医学副教授

45
h-index
2
Key Papers
2
Awards
2
Key Contributions

👥Biography 个人简介

Lydia Lynch is an immunologist who studies the intersection of metabolism, lipids, and innate cancer immunity with a focus on how adipose tissue and metabolic states influence anti-tumor immune responses. Her laboratory has characterized how lipid antigens presented by CD1d activate iNKT cells, and how obesity and adipose tissue in the tumor microenvironment impair immune surveillance by suppressing NKT cell function. Lynch has identified free fatty acids as immunosuppressive mediators produced by adipocytes that prevent anti-tumor NKT cell activation, connecting the obesity-cancer epidemiological link to specific immune evasion mechanisms.

Share:

🧪Research Fields 研究领域

NKT cells and tumorNKT细胞与肿瘤
immunometabolism免疫代谢
lipid antigens tumor脂质抗原肿瘤
obesity and cancer immunity肥胖与癌症免疫
tumor adipose microenvironment肿瘤脂肪微环境

🎓Key Contributions 主要贡献

Adipose Tissue Immune Suppression in Cancer

Discovered that adipose tissue in the tumor microenvironment produces free fatty acids that directly suppress NKT cell anti-tumor function, providing a mechanistic link between obesity, adipose-rich tumors, and impaired anti-cancer immunity.

NKT Cell Lipid Antigen Biology

Characterized how iNKT cells respond to lipid antigens via CD1d and how alterations in lipid presentation in cancer escape from iNKT cell-mediated immune surveillance.

Representative Works 代表性著作

[1]

Adipose Tissue Invariant NKT Cells Protect against Diet-induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

Immunity (2012)

NKT cells in adipose tissue immune regulation.

[2]

Tumor Microenvironmental Immunosuppression by Free Fatty Acids

Nature Immunology (2016)

Adipose-derived free fatty acid-mediated immune suppression in cancer.

🏆Awards & Recognition 奖项与荣誉

🏆Health Research Board Ireland Award
🏆Science Foundation Ireland President of Ireland Young Research Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

Related Experts 相关专家

Faisal Mahmood

Brigham and Women's Hospital; Harvard Medical School

Computational Pathology — Deep Learning for Whole-Slide Image Analysis and Tumor Microenvironment CharacterizationFoundation Models for Pathology — CONCH and TITAN Vision-Language Models for Oncology

Kun-Hsing Yu

Harvard Medical School; Brigham and Women's Hospital

Multimodal Oncology AI — Integrating Pathology Images, Genomics, Proteomics, and Clinical RecordsAI Pathology-Genomics Integration — Predicting Molecular Alterations from Histomorphology

Ziad Obermeyer

University of California, Berkeley; UC San Francisco

Algorithmic Bias in Healthcare AI — Racial Disparities in Predictive Risk ScoresPredictive Models for Cancer and Critical Illness — Machine Learning in Clinical Practice

Andrew H. Beck

PathAI; Harvard Medical School (formerly)

PathAI — Founding and Scientific Direction of AI-Powered Pathology PlatformDeep Learning for Pathology Biomarker Discovery — TILs, Fibrosis, and Tumor Architecture

关注 莉迪亚·林奇 的研究动态

Follow Lydia Lynch's research updates

留下邮箱，当我们发布与 Lydia Lynch（Harvard Medical School / Brigham and Women's Hospital）相关的新研究或访谈时，我们会通知你。

我们不会泄露你的信息，也不会发送无关内容。随时可以退订。

Explore More Experts

Discover the researchers shaping the future of cancer treatment

Browse All ExpertsRead Research Insights