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research / researchbreast cancer stem cells

Max S. Wicha

马克斯·维查

MD

🏢University of Michigan Rogel Cancer Center(密歇根大学罗杰癌症中心)🌐USA

Distinguished Professor of Oncology肿瘤学杰出教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Max Wicha is a pioneer of the cancer stem cell (CSC) field who identified cancer stem cells in human breast tumors and established the landmark functional assays and surface markers (CD44+/CD24- and ALDH activity) used worldwide to prospectively isolate breast CSCs. His laboratory demonstrated that breast CSCs exist in distinct epithelial and mesenchymal states interconnected by EMT plasticity, and that IL-6/JAK/STAT3 and Notch signaling maintain the CSC niche. Wicha has led clinical trials targeting CSC pathways including Notch, Hedgehog, and IL-6, advancing the CSC hypothesis from bench to therapeutic testing.

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🧪Research Fields 研究领域

breast cancer stem cells乳腺癌干细胞
ALDH CSC markersALDH CSC标志物
EMT and stemnessEMT与干性
IL-6/JAK/STAT3 CSC signalingIL-6/JAK/STAT3 CSC信号
CSC clinical targetingCSC临床靶向

🎓Key Contributions 主要贡献

Breast Cancer Stem Cell Identification

Identified CD44+/CD24- and high ALDH activity as markers of breast cancer stem cells capable of tumor initiation, metastasis, and therapy resistance, establishing functional CSC assays adopted globally.

CSC Plasticity and EMT Connection

Demonstrated that breast CSCs exist in epithelial and mesenchymal states with distinct marker profiles and that EMT drives interconversion, revealing CSC plasticity as a mechanism of therapeutic resistance.

Representative Works 代表性著作

[1]

Prospective Identification of Tumorigenic Breast Cancer Cells

PNAS (2003)

Landmark identification of breast cancer stem cells by CD44/CD24 markers.

[2]

Epithelial Plasticity in Cancer Stem Cells: From EMT to MET

Cell Stem Cell (2013)

CSC plasticity through EMT/MET interconversion in breast cancer.

🏆Awards & Recognition 奖项与荣誉

🏆AACR Clowes Memorial Award
🏆ASCO Distinguished Scientist Award
🏆Bonnie Joe Fund Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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