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research / researchCancer Metabolism

Matthew G. Vander Heiden

马修·范德海登

MD, PhD

🏢MIT Koch Institute for Integrative Cancer Research(麻省理工学院科赫癌症综合研究所)🌐USA

Director, Koch Institute; Professor of Biology科赫研究所所长；生物学教授

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h-index
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Key Papers
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Awards
2
Key Contributions

👥Biography 个人简介

Matthew Vander Heiden, MD, PhD directs the Koch Institute at MIT and is a leading authority on how cancer cells rewire metabolism to support rapid proliferation. His laboratory has made foundational contributions to understanding one-carbon metabolism, serine biosynthesis, and nutrient dependencies in tumors, informing strategies to target cancer-specific metabolic vulnerabilities.

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🧪Research Fields 研究领域

Cancer Cell Metabolism癌细胞代谢
Glutamine Metabolism谷氨酰胺代谢
mTOR SignalingmTOR信号
Serine Hydroxymethyltransferase (SHMT)丝氨酸羟甲基转移酶(SHMT)
Nucleotide Biosynthesis核苷酸生物合成

🎓Key Contributions 主要贡献

Warburg Effect Mechanism

Provided key mechanistic insights into why proliferating cells favor aerobic glycolysis, demonstrating that the Warburg effect supports biosynthetic precursor generation rather than energy production per se.

Serine and One-Carbon Metabolism

Characterized how SHMT-mediated serine catabolism fuels one-carbon units for nucleotide synthesis and redox balance, identifying SHMT2 as a cancer dependency.

Representative Works 代表性著作

[1]

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Science (2009)

Reframed the Warburg effect as a proliferative adaptation to support biomass synthesis, highly cited across cancer biology.

[2]

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Science (2012)

Demonstrated that glycine consumption correlates with proliferation rate, highlighting one-carbon metabolism as a cancer vulnerability.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Outstanding Investigator Award
🏆American Cancer Society Research Scholar
🏆Pew Scholar in Biomedical Sciences
🏆AACR Team Science Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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