Massimiliano Mazzone
马西米利亚诺·马佐内
PhD
Professor & VIB Group Leader, Laboratory of Tumor Microenvironment and Therapeutic Resistance教授兼VIB研究组长，肿瘤微环境与治疗耐药实验室
👥Biography 个人简介
Distinguished researcher at VIB-KU Leuven focusing on tumor vessel normalization and macrophage metabolic reprogramming. Mazzone showed that PHD2 haplodeficiency in macrophages promotes vessel normalization and that rewiring TAM metabolism via PFKFB3 converts immunosuppressive macrophages into anti-tumor effectors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Vascular Normalization via Macrophage PHD2
Demonstrated that PHD2 haplodeficiency in macrophages promotes vessel normalization, reduces tumor hypoxia, enhances T cell infiltration, and synergizes with chemotherapy and checkpoint blockade.
Macrophage Glycolytic Reprogramming
Showed that PFKFB3 overexpression in TAMs rewires glycolysis, converting immunosuppressive M2-like macrophages to inflammatory anti-tumor states capable of supporting cytotoxic immune responses.
Representative Works 代表性著作
Phd2 haplodeficiency in endothelial cells and macrophages normalises tumour vasculature and improves anti-tumour immunity
EMBO Molecular Medicine (2018)
PHD2 targeting in macrophages normalizes tumor vessels, enhances immune cell infiltration, and improves checkpoint immunotherapy response in preclinical models.
Macrophage metabolism controls tumor blood vessel morphogenesis
Cell Metabolism (2020)
Established mechanistic links between macrophage metabolic state, VEGF production, and tumor vascular architecture with direct therapeutic implications.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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