Marina Pasca di Magliano
玛丽娜·帕斯卡·迪·马利亚诺
PhD
Professor of Surgery and Cell & Developmental Biology; Co-Leader, Tumor Biology Program外科学及细胞与发育生物学教授；肿瘤生物学项目联合负责人
👥Biography 个人简介
Marina Pasca di Magliano, PhD is a Professor at the University of Michigan and a world-leading expert in the pancreatic cancer tumor microenvironment (TME). Her laboratory uses sophisticated mouse models, single-cell transcriptomics, and spatial genomics to dissect the cellular and molecular interactions among cancer cells, stellate cells, fibroblasts, macrophages, and T cells within PDAC tumors. Her research has transformed the understanding of how the desmoplastic stroma and myeloid-rich TME drive immune evasion in pancreatic cancer, generating mechanistic insights that underpin the design of novel immunotherapy combinations currently in clinical trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Single-Cell Landscape of the PDAC Microenvironment
Generated comprehensive single-cell RNA-sequencing atlases of human and mouse PDAC tumors that revealed the diversity of cancer-associated fibroblast and myeloid cell populations, their functional states, and their communication networks with tumor and immune cells.
Macrophage Reprogramming and Immune Evasion
Defined how tumor-derived signals polarize macrophages toward immunosuppressive phenotypes in PDAC, and demonstrated that re-educating macrophages via CSF1R blockade or other strategies can sensitize tumors to checkpoint immunotherapy.
Hedgehog and Kras Signaling in Pancreatic Stroma
Elucidated the role of Hedgehog pathway signaling in pancreatic stellate cell activation and desmoplasia, revealing context-dependent stromal functions that must be considered in anti-stromal therapeutic approaches.
Representative Works 代表性著作
Diverse Cellular and Molecular Programs of the Pancreatic Cancer Microenvironment
Cancer Cell (2022)
Single-cell transcriptomic atlas delineating the heterogeneity of cancer-associated fibroblasts and myeloid cells in PDAC and their functional implications for immune exclusion.
Targeting Macrophage Polarization to Sensitize Pancreatic Cancer to Immunotherapy
Nature Cancer (2023)
Mechanistic study showing that CSF1R inhibitor-mediated macrophage reprogramming converts the PDAC TME from immunosuppressed to inflamed, enabling T cell infiltration and anti-tumor immunity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Andrew H. Beck
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关注 玛丽娜·帕斯卡·迪·马利亚诺 的研究动态
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留下邮箱，当我们发布与 Marina Pasca di Magliano（University of Michigan Rogel Cancer Center）相关的新研究或访谈时，我们会通知你。
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