Marie-Catherine Vozenin
玛丽-凯瑟琳·沃兹宁
PhD
Professor of Radiation Biology; Head, Radio-Oncology Laboratory放射生物学教授；放射肿瘤学实验室主任
👥Biography 个人简介
Marie-Catherine Vozenin is the world's foremost pioneer of FLASH radiotherapy, having conducted the foundational preclinical studies demonstrating that ultra-high dose rate radiation (>40 Gy/s) spares normal tissues while maintaining tumor control. Her work at CHUV established the FLASH effect as a reproducible biological phenomenon and led directly to the first human FLASH treatment case in 2019. She has driven mechanistic investigation of the oxygen depletion hypothesis and translated FLASH from concept to clinical reality.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FLASH Effect Discovery and Characterization
Led seminal studies in mice and cats demonstrating that FLASH irradiation at ultra-high dose rates produces dramatically less normal tissue toxicity—including intestinal damage, lung fibrosis, and neurocognitive effects—than conventional dose-rate radiation while preserving equivalent tumor control.
First Human FLASH Treatment
Co-led the team that administered the world's first compassionate FLASH radiotherapy treatment to a human patient with cutaneous lymphoma in 2019, validating the FLASH effect in a clinical setting.
Oxygen Depletion Mechanism
Advanced the leading mechanistic hypothesis that FLASH's normal tissue sparing arises from transient radio-chemical oxygen depletion at ultra-high dose rates, reducing hydroxyl radical formation in oxygenated normal tissues.
Representative Works 代表性著作
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Science Translational Medicine (2014)
Landmark paper establishing the FLASH effect in vivo, demonstrating superior normal tissue sparing with equivalent tumor response—the foundational publication for the FLASH radiotherapy field.
Advantageous biochemical and biological outcomes of FLASH versus conventional proton irradiation in experimental models of lung and intestine
Radiotherapy and Oncology (2020)
Extended FLASH benefit demonstration to proton beam delivery, bridging ultra-high dose rate electron and proton therapy.
First human treatment with FLASH-RT: report of the Lausanne case
International Journal of Radiation Oncology Biology Physics (2021)
Clinical report of the first human FLASH radiotherapy case, marking a historic milestone in translational radiation biology.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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