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research / researchmelanoma tumor microenvironment models

Marcus Bosenberg

马库斯·博森伯格

MD, PhD

🏢Yale School of Medicine(耶鲁大学医学院)🌐USA

Professor of Pathology, Dermatology, and Immunobiology病理学、皮肤科与免疫生物学教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Marcus Bosenberg is a melanoma pathologist and tumor immunologist who developed the BRAFV600E/PTEN knockout GEM (Tamoxifen-inducible genetically engineered mouse) model of melanoma that recapitulates the immunosuppressive tumor microenvironment of human melanoma with low TIL infiltration. This model was instrumental in demonstrating why immunotherapy can fail and in testing combination strategies to convert cold tumors into hot ones. Bosenberg has used this model to characterize how BRAF and PTEN mutations cooperate to create the immunosuppressive TME and has identified strategies including radiation and targeted therapy to overcome immune exclusion.

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🧪Research Fields 研究领域

melanoma mouse models黑色素瘤小鼠模型
BRAF melanoma tumor immunologyBRAF黑色素瘤肿瘤免疫学
tumor microenvironment modeling肿瘤微环境建模
BRAFV600E/PTEN melanomaBRAFV600E/PTEN黑色素瘤
immune cold tumors免疫冷肿瘤

🎓Key Contributions 主要贡献

Immune-Cold Melanoma Mouse Model

Developed the BRAFV600E/PTEN GEM melanoma model with immune exclusion phenotype, providing a critical preclinical tool for studying immunosuppressive TME mechanisms and testing combination strategies to sensitize cold tumors to immunotherapy.

PTEN Loss and Immunosuppression

Demonstrated that PTEN loss in melanoma activates PI3K/AKT signaling that reduces CCL5/CXCL10 secretion, suppresses T cell trafficking into tumors, and creates immune exclusion, identifying PI3K signaling as a determinant of immunotherapy resistance.

Representative Works 代表性著作

[1]

PTEN Loss Promotes Immune Resistance of Melanomas through Inhibition of an ATF2 Transcriptional Network

Cell (2015)

PTEN loss mechanism of immune exclusion in melanoma.

[2]

Targeting BRAF/MEK Signaling in BRAFV600E Melanoma: Impact on the Tumor Microenvironment

Cancer Immunology Research (2016)

Targeted therapy effects on melanoma TME immunology.

🏆Awards & Recognition 奖项与荣誉

🏆Society for Melanoma Research Innovation Award
🏆Yale Cancer Center Research Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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