Manish Shah
马尼什·沙阿
MD
Bartlett Family Associate Professor of GI Oncology; Director, GI Oncology Program消化系统肿瘤学巴特利特家族副教授；消化系统肿瘤项目主任
👥Biography 个人简介
Dr. Manish Shah is a leading gastric cancer specialist at Weill Cornell Medicine with internationally recognized expertise in HER2-targeted therapy, EBV-associated gastric cancer, and translational oncology. He has led major NCI cooperative group and industry trials that have advanced molecular subtype-guided treatment.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Molecular Subtyping of Gastric Cancer
Translated TCGA genomic subtypes of gastric cancer into clinical trial design, establishing EBV-positive and HER2-amplified subtypes as distinct therapeutic targets.
HER2-Directed Therapy Beyond First Line
Led studies evaluating continued HER2 blockade and novel HER2-directed agents in previously treated gastric cancer, informing second-line treatment selection.
Representative Works 代表性著作
Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction cancer (KEYNOTE-811)
Lancet (2023)
Reported positive OS data for triple combination in HER2-positive gastric/GEJ cancer, establishing a new first-line standard of care.
Molecular determinants of response to anti-PD-L1 therapy in gastric cancer
Nature Medicine (2020)
Identified genomic and immune biomarkers predictive of checkpoint inhibitor response in gastric cancer, guiding patient selection.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Health / David Geffen School of Medicine
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Johanna Bendell
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