Lydia Lynch
莉迪亚·林奇
PhD
Associate Professor of Medicine医学副教授
👥Biography 个人简介
Lydia Lynch is a leading immunometabolism researcher who investigates how metabolic status shapes immune cell function in cancer and obesity. Her lab discovered that lipid-rich tumor microenvironments impair NK cell anti-tumor activity by disrupting fatty acid oxidation, linking obesity to cancer immune evasion.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Lipid Metabolism and NK Cell Function
Discovered that excess lipid accumulation in the tumor microenvironment impairs NK cell cytotoxicity by disrupting fatty acid oxidation, revealing a metabolic mechanism of immune evasion.
Obesity-Cancer Immune Link
Established that obesity-associated hyperlipidemia suppresses NK cell and T cell anti-tumor immunity, providing a mechanistic explanation for elevated cancer risk in obese individuals.
Fatty Acid Oxidation in Immune Cells
Demonstrated that promoting fatty acid oxidation in tumor-infiltrating NK cells and T cells restores their anti-tumor function, identifying a therapeutic strategy to enhance cancer immunotherapy.
Representative Works 代表性著作
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
Immunity (2012)
Revealed how NKT cells in adipose tissue regulate metabolic homeostasis and inflammation in obesity.
Lipid-induced IL-12 production activates T cells and enables cancer therapy
Cancer Cell (2015)
Demonstrated that lipid metabolism in dendritic cells controls IL-12 production and downstream anti-tumor T cell responses.
Obesity-associated immunosuppression: a metabolic perspective
Nature Reviews Immunology (2020)
Comprehensive framework explaining how metabolic changes in obesity systematically suppress anti-tumor immunity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Massachusetts Institute of Technology
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Matthew Vander Heiden
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