research / researchCancer Metabolism

Lydia Lynch

莉迪亚·林奇

PhD

🏢Harvard Medical School / Brigham and Women's Hospital(哈佛医学院/布莱根妇女医院)🌐USA

Associate Professor of Medicine医学副教授

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

Lydia Lynch, PhD is an Associate Professor at Harvard Medical School and Brigham and Women's Hospital. Her laboratory investigates how obesity and excess lipid accumulation reprogram immune cell metabolism, particularly NK cells and T cells, to suppress anti-tumor immunity. Her work bridges cancer metabolism, immunology, and the obesity-cancer axis.

🧪Research Fields 研究领域

Obesity and Tumor Metabolism肥胖与肿瘤代谢

NK Cell Lipid MetabolismNK细胞脂质代谢

Immune Cell Metabolic Reprogramming免疫细胞代谢重编程

Adipose Tissue and Immunity脂肪组织与免疫

Tumor Microenvironment Metabolism肿瘤微环境代谢

🎓Key Contributions 主要贡献

NK Cell Lipid Metabolism in Obesity

Showed that obesity causes lipid accumulation in NK cells that impairs their mitochondrial function and cytotoxic capacity, providing a mechanistic link between obesity and reduced cancer immunosurveillance.

Adipose Tissue Immune Regulation

Characterized how visceral adipose tissue creates an immunosuppressive microenvironment that promotes tumor immune evasion, identifying new targets for obesity-associated cancers.

Representative Works 代表性著作

[1]

Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity

Cell (2016)

Demonstrated that obesity-driven lipid accumulation in NK cells suppresses cytotoxic function, linking adiposity to impaired cancer immunosurveillance.

[2]

Metabolic reprogramming of tumor-infiltrating lymphocytes by lipids in the tumor microenvironment

Nature Immunology (2021)

Characterized how lipid-rich tumor microenvironments metabolically exhaust immune effector cells, limiting immunotherapy efficacy.

🏆Awards & Recognition 奖项与荣誉

🏆European Research Council Starting Grant

🏆Wellcome Trust Career Development Award

🏆Science Foundation Ireland Principal Investigator Award

🏆AACR-TNBC Foundation Research Grant

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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