research / researchTumor Microenvironment

Lisa M. Coussens

丽莎·库森斯

PhD

🏢OHSU Knight Cancer Institute(俄勒冈健康与科学大学奈特癌症研究所)🌐USA

Chair, Department of Cell, Developmental & Cancer Biology; Associate Director, Basic Research细胞发育与癌症生物学系主任；基础研究副主任

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

Pioneer in tumor-associated macrophage biology at OHSU Knight Cancer Institute. Coussens defined how myeloid cells and chronic inflammation sculpt the tumor microenvironment to promote breast and other cancers, advancing CSF1R-targeted therapeutic strategies and myeloid reprogramming approaches.

🧪Research Fields 研究领域

Tumor-Associated Macrophages肿瘤相关巨噬细胞

TAM PolarizationTAM极化

CSF1R InhibitionCSF1R抑制

Tumor Inflammation肿瘤炎症

Breast Cancer TME乳腺癌肿瘤微环境

🎓Key Contributions 主要贡献

TAM Polarization & CSF1R Inhibition

Demonstrated that CSF1R-dependent macrophages are essential drivers of mammary tumor progression and metastasis, establishing the preclinical rationale for CSF1R inhibitors in combination immunotherapy regimens.

Tumor Inflammation & Immune Evasion

Characterized protease-mediated remodeling of the extracellular matrix by TAMs, linking chronic inflammation to immune checkpoint resistance and identifying actionable targets in solid tumors.

Representative Works 代表性著作

[1]

Paradoxical roles of the immune system during cancer development

Nature Reviews Cancer (2022)

Comprehensive review updating models of dual pro- and anti-tumor immune functions, emphasizing myeloid cell heterogeneity in the solid tumor TME.

[2]

CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Sensitizes to Anti-PD-1

Cancer Cell (2020)

Showed that CSF1R inhibition converts immunosuppressive TAMs to an inflammatory phenotype, synergizing with checkpoint blockade in breast cancer models.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Outstanding Investigator Award (R35)

🏆AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship

🏆Elected Member, National Academy of Medicine

🏆Susan G. Komen Scholar Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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