research / researchCancer Metabolism

Lewis C. Cantley

刘易斯·坎特利

PhD

🏢Weill Cornell Medicine / Meyer Cancer Center(威尔康奈尔医学院/迈耶癌症中心)🌐USA

Professor of Cancer Biology; Director Emeritus, Meyer Cancer Center癌症生物学教授；迈耶癌症中心荣誉主任

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h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

Lewis Cantley, PhD is a pioneering biochemist at Weill Cornell Medicine who discovered phosphoinositide 3-kinase (PI3K), one of the most frequently mutated enzymes in human cancer. His foundational work on PI3K/AKT/mTOR signaling transformed understanding of cancer metabolism, insulin resistance, and tumor growth, and catalyzed the development of PI3K inhibitors as cancer therapeutics.

🧪Research Fields 研究领域

PI3-Kinase DiscoveryPI3激酶发现

mTOR PathwaymTOR通路

Insulin Signaling and Cancer胰岛素信号与癌症

Fasting and Cancer Metabolism禁食与癌症代谢

Glucose Metabolism葡萄糖代谢

🎓Key Contributions 主要贡献

PI3-Kinase Discovery

Discovered and characterized phosphoinositide 3-kinase (PI3K) and its activation by oncoproteins, establishing the PI3K/AKT/mTOR axis as a central driver of cancer cell growth and metabolism.

Fasting and Dietary Interventions

Demonstrated that insulin and IGF-1 signaling driven by dietary sugar promotes tumor growth and that fasting or low-sugar diets can enhance the efficacy of cancer therapy through metabolic mechanisms.

Representative Works 代表性著作

[1]

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Genes & Development (1998)

Established PI3K/Akt as a key survival pathway suppressing apoptosis in cancer cells.

[2]

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Nature (2020)

Showed that dietary intervention mimicking fasting sensitizes breast tumors to hormone therapy via metabolic and endocrine mechanisms.

🏆Awards & Recognition 奖项与荣誉

🏆Lasker~Koshland Special Achievement Award in Medical Science

🏆Breakthrough Prize in Life Sciences

🏆Member, National Academy of Sciences

🏆Member, National Academy of Medicine

🏆Pezcoller Foundation-AACR International Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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