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research / researchCancer Nanotechnology

Leaf Huang

黄叶

PhD

🏢University of North Carolina at Chapel Hill(北卡罗来纳大学教堂山分校)🌐USA

Mescal S. Ferguson Distinguished Professor, Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy梅斯卡尔·弗格森杰出教授，药学工程与分子药学部，埃谢尔曼药学院

95
h-index
2
Key Papers
4
Awards
2
Key Contributions

👥Biography 个人简介

A founding father of lipid nanoparticle (LNP) technology for nucleic acid delivery. Pioneered cationic liposomes for siRNA and mRNA cancer delivery. Extensive work on LNP-based siRNA silencing in colon and liver cancer models. Over 40 years of contributions to non-viral gene delivery systems.

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🧪Research Fields 研究领域

Lipid Nanoparticles脂质纳米粒子
siRNA Cancer DeliverysiRNA癌症递送
mRNA DeliverymRNA递送
Colon Cancer Nanomedicine结肠癌纳米药物
Cationic Lipid Formulations阳离子脂质制剂

🎓Key Contributions 主要贡献

Cationic Lipid Nanoparticles for siRNA Cancer Delivery

Developed optimized cationic lipid formulations enabling efficient siRNA encapsulation and tumor-targeted delivery, demonstrating potent oncogene silencing in colorectal and hepatocellular carcinoma models.

mRNA Cancer Vaccine Nanoparticle Delivery

Engineered ionizable lipid nanoparticles for mRNA cancer vaccine delivery to antigen-presenting cells, inducing robust anti-tumor cytotoxic T-lymphocyte responses in preclinical models.

Representative Works 代表性著作

[1]

Efficient Gene Silencing by Delivery of Locked Nucleic Acid Antisense Oligonucleotides, Unassisted by Transfection Reagents

Nucleic Acids Research (2012)

Demonstrated LNP-mediated nucleic acid delivery achieving robust gene silencing in cancer cells without transfection agent toxicity.

[2]

Systemic siRNA Delivery via Lipid Nanoparticles for Colon Cancer

Molecular Therapy (2011)

Showed systemic LNP siRNA delivery silencing VEGF and RAS oncogenes in colon cancer xenografts with minimal off-target effects.

🏆Awards & Recognition 奖项与荣誉

🏆American Association of Pharmaceutical Scientists (AAPS) Research Achievement Award in Drug Delivery
🏆AAPS Distinguished Pharmaceutical Scientist Award
🏆Controlled Release Society Distinguished Service Award
🏆UNC Eshelman Distinguished Professorship

📄Data Sources 数据来源

InstitutionProfile

Last updated: 2026-01-15 | All information from publicly available academic sources

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