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research / researchTumor Microenvironment

Klaus Ley

克劳斯·雷

MD

🏢La Jolla Institute for Immunology(拉荷亚免疫学研究所)🌐USA

Professor & Director, Division of Inflammation Biology教授兼炎症生物学部门主任

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Leading authority on monocyte and macrophage differentiation at the La Jolla Institute for Immunology. Ley defined the Ly6C-high and Ly6C-low monocyte subsets and identified NR4A1 and KLF4 transcription factors controlling macrophage fate decisions underpinning TAM recruitment in tumors.

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🧪Research Fields 研究领域

Monocyte Subset Differentiation单核细胞亚群分化
Macrophage Transcriptional Control巨噬细胞转录调控
Inflammatory Monocytes炎性单核细胞
Integrin Signaling整合素信号
Myeloid Cell Trafficking髓系细胞迁移

🎓Key Contributions 主要贡献

Monocyte Subset Trafficking & Differentiation

Defined the Ly6C-high and Ly6C-low monocyte subsets and their distinct trafficking programs, establishing the molecular basis for monocyte-to-macrophage differentiation in inflamed tissues including the tumor microenvironment.

Transcriptional Control of Myeloid Identity

Identified NR4A1 and KLF4 as key transcription factors governing monocyte patrolling behavior and macrophage polarization, providing molecular targets for TME reprogramming strategies.

Representative Works 代表性著作

[1]

Monocyte and macrophage heterogeneity

Nature Reviews Immunology (2011)

Definitive review establishing the functional dichotomy of monocyte subsets and the transcriptional programs controlling their fate in health, inflammation, and cancer.

[2]

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

Science (2013)

Showed NR4A1 transcription factor is required for the patrolling Ly6C-low monocyte subset, linking nuclear receptor signaling to tissue surveillance and TME seeding.

🏆Awards & Recognition 奖项与荣誉

🏆MERIT Award, National Heart, Lung, and Blood Institute
🏆Distinguished Scientist Award, American Heart Association
🏆Ulf von Euler Lecture Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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