research / researchCancer Metabolism

Kathryn E. Wellen

凯瑟琳·韦伦

PhD

🏢University of Pennsylvania Perelman School of Medicine(宾夕法尼亚大学佩雷尔曼医学院)🌐USA

Professor of Cancer Biology癌症生物学教授

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

Kathryn Wellen, PhD is a Professor at the University of Pennsylvania whose research illuminates how intracellular acetyl-CoA levels couple cellular metabolism to epigenetic gene regulation via histone acetylation. Her work has defined how nutrient availability — particularly glucose — influences chromatin state and gene expression in cancer and metabolic disease.

🧪Research Fields 研究领域

Acetyl-CoA Metabolism乙酰辅酶A代谢

Histone Acetylation组蛋白乙酰化

Epigenetic Metabolic Regulation代谢的表观遗传调控

Obesity and Cancer Metabolism肥胖与癌症代谢

Glucose and Fatty Acid Metabolism葡萄糖与脂肪酸代谢

🎓Key Contributions 主要贡献

Acetyl-CoA and Histone Acetylation

Demonstrated that nuclear acetyl-CoA, derived from glucose via ATP-citrate lyase (ACLY), directly controls histone acetylation levels and regulates gene expression in response to nutrient availability.

Obesity-Cancer Metabolic Link

Characterized how obesity-associated metabolic changes alter acetyl-CoA pools and epigenetic states, providing mechanistic insight into obesity as a cancer risk factor.

Representative Works 代表性著作

[1]

ATP-citrate lyase links cellular metabolism to histone acetylation

Science (2009)

Landmark discovery showing that ACLY-derived nuclear acetyl-CoA controls histone acetylation, directly linking metabolism to epigenetic regulation.

[2]

Metabolic regulation of transcription through compartmentalized acetyl-CoA metabolism

Science (2022)

Resolved how spatial control of acetyl-CoA pools enables distinct transcriptional programs in different cellular compartments.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Outstanding Investigator Award

🏆American Cancer Society Research Scholar

🏆Pew Scholar in Biomedical Sciences

🏆AACR NextGen Grant

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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