Junjie Chen
陈俊杰
PhD
Professor and Chair, Department of Experimental Radiation Oncology实验放射肿瘤学系教授兼系主任
👥Biography 个人简介
Junjie Chen is a world-leading expert in DNA damage response and double-strand break repair. His laboratory at MD Anderson has made seminal contributions to understanding how cells choose between NHEJ and homologous recombination repair pathways after ionizing radiation. He discovered key regulatory mechanisms involving ATM kinase activation, 53BP1, and BRCA1 that govern DSB repair pathway selection, work that has profoundly shaped our understanding of radiation sensitivity and resistance in cancer cells.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DSB Repair Pathway Choice
Elucidated the molecular antagonism between 53BP1 and BRCA1 that determines whether cells use NHEJ or HR to repair radiation-induced double-strand breaks, explaining differential radiosensitivity between cell types.
ATM Kinase Signaling Network
Mapped the ATM-dependent phosphorylation cascade triggered by ionizing radiation, identifying hundreds of substrates and revealing how the DNA damage checkpoint coordinates repair with cell cycle arrest.
Radiosensitization Targets
Identified synthetic lethal interactions between HR deficiency and PARP inhibition that can be exploited to sensitize tumors with BRCA mutations to radiation therapy.
Representative Works 代表性著作
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
Cell (2010)
Landmark study demonstrating the molecular basis for 53BP1/BRCA1 antagonism in DSB repair pathway choice, highly cited in radiation biology.
ATM substrate analysis reveals extensive protein networks responsive to DNA damage
Science (2007)
Comprehensive proteomics study mapping the ATM-dependent phosphoproteome after ionizing radiation exposure.
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Cell (2007)
Identified ubiquitin-mediated chromatin remodeling as essential for recruiting repair factors to DNA damage sites.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Andrew H. Beck
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留下邮箱，当我们发布与 Junjie Chen（The University of Texas MD Anderson Cancer Center）相关的新研究或访谈时，我们会通知你。
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