Mikael Pittet
米卡埃尔·皮泰
PhD
Professor of Pathology and Immunology; Director, Translational Cancer Research病理与免疫学教授；转化癌症研究主任
👥Biography 个人简介
Mikael Pittet is a leading authority on myeloid cell biology in the tumor microenvironment, with particular expertise in how tumor-associated neutrophils (TANs) and myeloid-derived suppressor cells (MDSCs) are educated by tumors to suppress anti-tumor immunity. His single-cell and spatial transcriptomic studies have resolved myeloid cell heterogeneity in human tumors, revealing TAN and MDSC subsets that correlate with immunotherapy resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
TAN Heterogeneity and Plasticity
Used single-cell RNA sequencing to define pro-tumor (N2) and anti-tumor (N1) tumor-associated neutrophil transcriptional states, identifying TGF-β as a key switch toward immunosuppressive phenotypes.
MDSC Mechanisms in Immunotherapy Resistance
Demonstrated that polymorphonuclear MDSCs expand in patients progressing on PD-1 blockade and suppress NK cell and T cell function via ROS and arginase-1.
Spatial Tumor Immunology
Pioneered spatial transcriptomic mapping of myeloid niches in human tumors, revealing how MDSC-rich exclusion zones physically prevent T cell infiltration.
Representative Works 代表性著作
Single-cell transcriptomic analysis of tumor-infiltrating myeloid cells reveals neutrophil polarization states
Nature Cancer (2022)
Defined seven neutrophil transcriptional states across 12 human tumor types, identifying an aged pro-tumor CXCR4hi TAN signature associated with poor immunotherapy response.
Myeloid cells in the tumor ecosystem
Science (2020)
Landmark perspective establishing the conceptual framework for myeloid cell education and reprogramming in the tumor microenvironment, outlining therapeutic targeting strategies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Andrew H. Beck
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