Jonathan Strosberg
乔纳森·斯特罗斯伯格
MD
Professor and Director, Neuroendocrine Tumor Program神经内分泌肿瘤项目主任兼教授
👥Biography 个人简介
Dr. Jonathan Strosberg is the principal investigator of the landmark NETTER-1 trial at Moffitt Cancer Center, which led to FDA approval of Lu-177 DOTATATE (Lutathera) for midgut NETs. He is a global leader in NET clinical trials and PRRT research, authoring extensively on NET treatment.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
NETTER-1 Trial Leadership
Led the NETTER-1 phase III trial as global principal investigator, demonstrating Lu-177 DOTATATE dramatically improved progression-free survival over high-dose octreotide in midgut NETs, directly enabling FDA approval.
NET Treatment Algorithm Development
Contributed to developing and refining sequential treatment algorithms for NETs, including optimal use of PRRT, somatostatin analogues, everolimus, and chemotherapy across NET subtypes.
Representative Works 代表性著作
177Lu-Dotatate for midgut neuroendocrine tumors (NETTER-1)
New England Journal of Medicine (2017)
Pivotal phase III trial led by Strosberg demonstrating Lu-177 DOTATATE reduced risk of disease progression or death by 79% vs high-dose octreotide, resulting in FDA and EMA approval.
Phase II study of streptozocin and doxorubicin followed by temozolomide in patients with metastatic pancreatic endocrine carcinomas
American Journal of Clinical Oncology (2011)
Sequential chemotherapy study informing treatment of advanced pancreatic NET, demonstrating activity of temozolomide-based regimens as salvage therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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