research / researchTumor Microenvironment

Johanna A. Joyce

约翰娜·乔伊斯

PhD

🏢Ludwig Institute for Cancer Research, University of Lausanne(路德维希癌症研究所，洛桑大学)🌐Switzerland

Member, Ludwig Institute for Cancer Research; Professor, Department of Oncology, UNIL路德维希癌症研究所成员；洛桑大学肿瘤学系教授

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

World authority on the brain tumor microenvironment at Ludwig Institute Lausanne, formerly at UCSF and Memorial Sloan Kettering. Joyce's lab defined how glioblastoma co-opts microglia and bone-marrow-derived macrophages to create an immunosuppressive niche and identified cathepsin proteases as TAM-driven invasion drivers.

🧪Research Fields 研究领域

Brain Tumor TME脑肿瘤微环境

Glioblastoma Macrophages胶质母细胞瘤相关巨噬细胞

Microglia in Cancer癌症中小胶质细胞

Cathepsin Proteases组织蛋白酶

Pediatric Brain Tumor Immunity儿科脑肿瘤免疫

🎓Key Contributions 主要贡献

Glioblastoma Macrophage & Microglia Heterogeneity

Distinguished brain-resident microglia from monocyte-derived TAMs in glioblastoma using fate-mapping and single-cell transcriptomics, revealing divergent immunosuppressive programs and differential therapeutic vulnerabilities.

Cathepsin Proteases in Brain Tumor Invasion

Demonstrated that cysteine cathepsins secreted by TAMs remodel the pericellular matrix to drive invasion and angiogenesis in GBM, establishing these enzymes as actionable TAM-derived therapeutic targets.

Representative Works 代表性著作

[1]

Microglia and macrophages in brain tumour biology

Nature Reviews Cancer (2021)

Definitive review distinguishing ontogeny and function of microglia versus monocyte-derived TAMs in high-grade glioma with therapeutic implications.

[2]

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Science (2023)

Comprehensive perspective on TME dynamics across tumor stages with focus on macrophage plasticity, meningeal immunity, and new therapeutic opportunities.

🏆Awards & Recognition 奖项与荣誉

🏆ERC Advanced Grant

🏆AACR Women in Cancer Research Award

🏆Elected Member, EMBO

🏆Swiss Cancer League Research Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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