research / researchCancer Metabolism

Jing Chen

陈静

PhD

🏢Emory University School of Medicine / Winship Cancer Institute(埃默里大学医学院/温希普癌症研究所)🌐USA

Professor of Hematology and Medical Oncology; Charles Howard Candler Professor血液学与肿瘤内科学教授；查尔斯·霍华德·坎德勒讲席教授

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

Jing Chen, PhD is a Charles Howard Candler Professor at Emory University and a pioneering investigator in cancer metabolic oncology. His laboratory made fundamental contributions to understanding IDH1 and IDH2 neomorphic mutations that generate the oncometabolite 2-hydroxyglutarate (2-HG), and characterized PKM2 as a regulator linking glycolysis to transcriptional reprogramming in cancer.

🧪Research Fields 研究领域

IDH1/IDH2 Neomorphic MutationsIDH1/IDH2新形态突变

2-Hydroxyglutarate (2-HG) Production2-羟基戊二酸(2-HG)生成

PKM2 and GlycolysisPKM2与糖酵解

Epigenetic Metabolic Dysregulation代谢的表观遗传失调

Oncometabolite Biology致癌代谢物生物学

🎓Key Contributions 主要贡献

IDH Neomorphic Mutations and 2-HG

Provided key biochemical characterization of how IDH1/IDH2 gain-of-function mutations catalyze 2-HG production, demonstrating that 2-HG inhibits TET demethylases and KDM histone demethylases to drive epigenetic cancer transformation.

PKM2 in Cancer Signaling

Discovered that PKM2, the cancer-associated pyruvate kinase isoform, translocates to the nucleus and functions as a transcriptional coactivator, directly linking glycolytic metabolism to oncogenic gene expression.

Representative Works 代表性著作

[1]

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Nature (2012)

Demonstrated that 2-HG produced by mutant IDH inhibits histone demethylases, establishing a mechanistic link between IDH mutation and epigenetic stem cell blockade in cancer.

[2]

PKM2 regulates chromosome segregation and mitosis in tumor cells

Science (2012)

Revealed a non-canonical nuclear function of PKM2 in regulating mitosis, demonstrating metabolic enzymes as moonlighting oncogenic regulators.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Outstanding Investigator Award

🏆Georgia Research Alliance Eminent Scholar

🏆AACR Award in Cancer Metabolism

🏆Winship Cancer Institute Distinguished Researcher Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

Related Experts 相关专家

Faisal Mahmood

Brigham and Women's Hospital; Harvard Medical School

Computational Pathology — Deep Learning for Whole-Slide Image Analysis and Tumor Microenvironment CharacterizationFoundation Models for Pathology — CONCH and TITAN Vision-Language Models for Oncology

Kun-Hsing Yu

Harvard Medical School; Brigham and Women's Hospital

Multimodal Oncology AI — Integrating Pathology Images, Genomics, Proteomics, and Clinical RecordsAI Pathology-Genomics Integration — Predicting Molecular Alterations from Histomorphology

Ziad Obermeyer

University of California, Berkeley; UC San Francisco

Algorithmic Bias in Healthcare AI — Racial Disparities in Predictive Risk ScoresPredictive Models for Cancer and Critical Illness — Machine Learning in Clinical Practice

Andrew H. Beck

PathAI; Harvard Medical School (formerly)

PathAI — Founding and Scientific Direction of AI-Powered Pathology PlatformDeep Learning for Pathology Biomarker Discovery — TILs, Fibrosis, and Tumor Architecture

关注陈静的研究动态

Follow Jing Chen's research updates

留下邮箱，当我们发布与 Jing Chen（Emory University School of Medicine / Winship Cancer Institute）相关的新研究或访谈时，我们会通知你。

Explore More Experts

Discover the researchers shaping the future of cancer treatment

Browse All Experts Read Research Insights

International Translational Oncology Exchange