Jesper B. Andersen
耶斯佩尔·安徒生
PhD
Professor; Head, Translational Liver Cancer Research Group教授；转化肝癌研究组组长
👥Biography 个人简介
Jesper B. Andersen, PhD is a professor at the University of Copenhagen's BRIC whose group is internationally recognized for elucidating the molecular heterogeneity and epigenetic landscape of cholangiocarcinoma (CCA). His laboratory identified several recurrent molecular subtypes of intrahepatic CCA with distinct driver alterations—including FGFR2 fusions and IDH1/2 mutations—and has dissected the stromal and immune microenvironmental features that influence prognosis and treatment response. His work has directly informed the clinical development of FGFR inhibitors and epigenetic therapies in biliary tract cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Molecular Subtyping of Cholangiocarcinoma
Generated comprehensive multi-omic maps of intrahepatic and extrahepatic CCA that revealed actionable molecular subtypes, enabling biomarker-stratified clinical trials and precision therapy approaches for this heterogeneous disease.
Epigenomic Regulation in Biliary Cancers
Characterized DNA methylation and chromatin remodeling landscapes in CCA, identifying epigenetically silenced tumor suppressor genes and proposing epigenetic reprogramming as a therapeutic vulnerability.
FGFR2 Fusion Biology
Defined the functional consequences of FGFR2 gene fusions in CCA cells, demonstrating oncogenic dependency and providing mechanistic rationale for clinical use of selective FGFR inhibitors such as pemigatinib and infigratinib.
Representative Works 代表性著作
Genomic and Molecular Landscape of Cholangiocarcinoma Identifies Distinct Subtypes
Nature Genetics (2021)
Landmark multi-omic analysis of 492 CCA tumors revealing molecular classification with clinical and therapeutic implications.
IDH Mutations Remodel the DNA Methylome and Drive Oncogenesis in Intrahepatic Cholangiocarcinoma
Cell Reports (2022)
Demonstrated how IDH1/2 mutations reshape the epigenome in CCA and identified downstream effectors as potential therapeutic targets.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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