research / researchTumor Microenvironment

Jeffrey V. Ravetch

杰弗里·拉维奇

MD, PhD

🏢The Rockefeller University(洛克菲勒大学)🌐USA

Theresa and Eugene M. Lang Professor; Head, Laboratory of Molecular Genetics and ImmunologyTheresa和Eugene M. Lang讲席教授；分子遗传学与免疫学实验室主任

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

World authority on antibody Fc receptors and macrophage-mediated anti-tumor effector functions at Rockefeller University. Ravetch's discoveries on activating versus inhibitory FcγRs and IgG glycosylation have directly guided engineering of next-generation therapeutic monoclonal antibodies for cancer.

🧪Research Fields 研究领域

Fc ReceptorsFc受体

Macrophage IgG Effector Function巨噬细胞IgG效应功能

Antibody-Mediated Cytotoxicity (ADCC)抗体依赖细胞毒性(ADCC)

Anti-Cancer Antibody Engineering抗癌抗体工程

IgG GlycosylationIgG糖基化

🎓Key Contributions 主要贡献

Activating & Inhibitory FcγR Biology

Cloned and characterized the family of activating and inhibitory Fc gamma receptors, defining the A:I ratio on macrophages and NK cells as a key determinant of antibody-dependent tumor killing efficacy.

IgG Glycosylation & Antibody Effector Function

Demonstrated that IgG Fc glycosylation profoundly modulates FcγR binding and macrophage ADCC, enabling rational engineering of anti-cancer antibodies with enhanced or attenuated tumor-killing activity.

Representative Works 代表性著作

[1]

Divergent immunoglobulin G subclass activity through selective Fc receptor binding

Science (2005)

Established the molecular basis for IgG subclass-dependent macrophage activation and defined A:I receptor ratios as predictors of therapeutic antibody efficacy in cancer.

[2]

Fc receptor targeting in oncology

Annual Review of Immunology (2021)

Comprehensive review translating FcγR biology into principles for engineering next-generation anti-tumor antibodies with optimized macrophage effector functions.

🏆Awards & Recognition 奖项与荣誉

🏆Crafoord Prize in Immunology

🏆Lasker-DeBakey Clinical Medical Research Award

🏆Paul Ehrlich and Ludwig Darmstaedter Prize

🏆AACR Award for Outstanding Achievement in Cancer Immunology

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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