Jean-Charles Soria
让-查尔斯·索里亚
MD, PhD
Executive Vice President, Late-Stage Oncology R&D后期肿瘤研发执行副总裁
👥Biography 个人简介
Professor Jean-Charles Soria is a world-renowned thoracic oncologist and drug developer. He led pivotal trials of osimertinib, alectinib, and durvalumab, transforming outcomes for EGFR- and ALK-mutated NSCLC while shaping the global oncology R&D pipeline at AstraZeneca.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR-Targeted Therapy Development
Led clinical development of osimertinib (FLAURA trial), establishing third-generation EGFR inhibition as the standard of care for EGFR-mutated NSCLC first-line treatment globally.
Immunotherapy in Lung Cancer
Principal investigator on PACIFIC trial with durvalumab post-chemoradiation in stage III NSCLC, creating a new category of curative-intent immunotherapy consolidation.
Early Phase Clinical Trials
Directed the Drug Development Department at Gustave Roussy, one of Europe's most productive early-phase oncology units, advancing multiple first-in-human trials.
Representative Works 代表性著作
Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer
New England Journal of Medicine (2018)
FLAURA trial establishing osimertinib as first-line standard of care for EGFR-mutant NSCLC with superior PFS and CNS activity over earlier-generation TKIs.
Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
New England Journal of Medicine (2017)
PACIFIC trial showing durvalumab consolidation significantly improved PFS and OS in unresectable stage III NSCLC after platinum-based chemoradiation.
Alectinib versus Crizotinib in Untreated ALK-Positive NSCLC
New England Journal of Medicine (2017)
ALEX trial contributions demonstrating alectinib superiority over crizotinib in ALK+ NSCLC, establishing a new first-line ALK inhibitor standard.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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