Jason Locasale
贾森·洛卡萨莱
PhD
Professor of Pharmacology and Cancer Biology药理学与癌症生物学教授
👥Biography 个人简介
Jason Locasale is a computational and experimental metabolomics expert who discovered critical links between one-carbon metabolism, epigenetic regulation, and cancer. His research revealed how diet-derived metabolites influence gene expression and tumor growth through epigenetic mechanisms.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
One-Carbon Metabolism in Cancer
Demonstrated that one-carbon metabolism generates methylation substrates that regulate epigenetic marks in cancer cells, linking metabolic flux to gene expression and tumor phenotype.
Serine Metabolism and Epigenetics
Showed that serine catabolism through the folate cycle provides one-carbon units critical for DNA and histone methylation, connecting amino acid metabolism to epigenetic reprogramming in tumors.
Diet-Epigenome-Cancer Axis
Established that dietary interventions alter one-carbon metabolite pools and epigenetic landscapes in tumors, providing a mechanistic basis for nutrition-based cancer prevention strategies.
Representative Works 代表性著作
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells
Cell Reports (2013)
Demonstrated that serine is the primary one-carbon donor for cancer cell proliferation, distinguishing its role from glycine.
Dietary methionine influences therapy in mouse cancer models and alters human metabolism
Nature (2019)
Showed that methionine restriction alters one-carbon metabolism in tumors and sensitizes them to chemotherapy.
Metabolic flux and the regulation of mammalian gene expression
Molecular Cell (2012)
Established that metabolic flux rates directly influence epigenetic regulation through metabolite-mediated enzyme activity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Matthew Vander Heiden
Massachusetts Institute of Technology
Lewis Cantley
Weill Cornell Medicine
Craig Thompson
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Matthew Vander Heiden
Massachusetts Institute of Technology
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