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research / researchCancer Metabolism

Jason W. Locasale

杰森·洛卡萨勒

PhD

🏢Duke University School of Medicine(杜克大学医学院)🌐USA

Professor of Pharmacology and Cancer Biology药理学与癌症生物学教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Jason Locasale, PhD is a Professor at Duke University whose research defines how one-carbon metabolism and dietary nutrients shape cancer cell epigenetics and proliferation. He has pioneered metabolomics approaches to understand how methionine restriction and folate metabolism influence cancer progression and treatment response, with translational implications for dietary interventions.

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🧪Research Fields 研究领域

One-Carbon Metabolism一碳代谢
Methionine Cycle甲硫氨酸循环
Dietary Interventions in Cancer饮食干预癌症
Cancer Metabolomics癌症代谢组学
Epigenetic Metabolic Regulation代谢的表观遗传调控

🎓Key Contributions 主要贡献

One-Carbon Metabolism and Methionine

Established that methionine availability controls SAM-dependent histone methylation and gene expression in cancer cells, demonstrating dietary methionine restriction as a potential therapeutic strategy.

Dietary Cancer Metabolomics

Developed computational and experimental frameworks to systematically analyze how diet-derived metabolites reprogram cancer cell metabolism, bridging nutritional science and cancer biology.

Representative Works 代表性著作

[1]

Serine, folate, and one-carbon metabolism in cancer

Nature Reviews Cancer (2013)

Comprehensive review establishing serine-driven one-carbon metabolism as a central cancer metabolic pathway and therapeutic target.

[2]

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Nature (2019)

Demonstrated that dietary methionine restriction synergizes with chemotherapy and radiation in tumor models, with biomarker validation in humans.

🏆Awards & Recognition 奖项与荣誉

🏆NCI Outstanding Investigator Award
🏆American Cancer Society Research Scholar
🏆Damon Runyon-Rachleff Innovation Award
🏆AACR Team Science Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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