Upcoming · By Invitation

International Translational Oncology Exchange

Boston · May 13, 202614:00 – 16:00 ET
Learn more →
←Back to Expert Scholars
research / researchchromosomal translocations in leukemia pioneer

Janet D. Rowley

简尼特·罗利

MD

🏢University of Chicago (Legacy)(芝加哥大学（历史）)🌐USA

Professor Emerita (1925-2013)名誉教授（1925-2013）

88
h-index
2
Key Papers
4
Awards
2
Key Contributions

👥Biography 个人简介

Janet Rowley was a pioneering cancer cytogeneticist who identified chromosomal translocations as causative events in leukemia, transforming understanding of the genetic basis of cancer. In 1972, she discovered that the Philadelphia chromosome in CML results from a specific reciprocal translocation t(9;22) rather than a chromosome deletion, and subsequently identified t(8;21) in AML and t(15;17) in acute promyelocytic leukemia. The t(15;17) discovery was the direct basis for retinoic acid differentiation therapy in APL, which cured a previously fatal leukemia. Rowley received the Presidential Medal of Freedom and National Medal of Science, and her discoveries directly enabled imatinib development by identifying BCR-ABL as the Philadelphia chromosome product.

Share:

🧪Research Fields 研究领域

Philadelphia chromosome费城染色体
chromosomal translocations染色体易位
AML cytogeneticsAML细胞遗传学
t(15;17) APLt(15;17) APL
cancer cytogenetics癌症细胞遗传学

🎓Key Contributions 主要贡献

Philadelphia Chromosome Translocation Identification

Identified that the Philadelphia chromosome results from reciprocal translocation t(9;22), establishing the molecular foundation for understanding BCR-ABL oncogenesis and directly enabling development of imatinib targeted therapy decades later.

APL t(15;17) Discovery and ATRA Therapy

Discovered t(15;17) in acute promyelocytic leukemia, identifying the PML-RARA fusion as the driver and enabling development of all-trans retinoic acid differentiation therapy that converts APL from uniformly fatal to curative.

Representative Works 代表性著作

[1]

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia

Nature (1973)

Identification of t(9;22) reciprocal translocation creating BCR-ABL in CML.

[2]

Identificaton of the Chromosomal Translocation t(15;17) in Acute Promyelocytic Leukemia

Science (1977)

Discovery of APL-defining t(15;17) translocation.

🏆Awards & Recognition 奖项与荣誉

🏆Presidential Medal of Freedom
🏆National Medal of Science
🏆Lasker Special Achievement Award
🏆Canada Gairdner International Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

Related Experts 相关专家

Faisal Mahmood

Brigham and Women's Hospital; Harvard Medical School

Computational Pathology — Deep Learning for Whole-Slide Image Analysis and Tumor Microenvironment CharacterizationFoundation Models for Pathology — CONCH and TITAN Vision-Language Models for Oncology

Kun-Hsing Yu

Harvard Medical School; Brigham and Women's Hospital

Multimodal Oncology AI — Integrating Pathology Images, Genomics, Proteomics, and Clinical RecordsAI Pathology-Genomics Integration — Predicting Molecular Alterations from Histomorphology

Ziad Obermeyer

University of California, Berkeley; UC San Francisco

Algorithmic Bias in Healthcare AI — Racial Disparities in Predictive Risk ScoresPredictive Models for Cancer and Critical Illness — Machine Learning in Clinical Practice

Andrew H. Beck

PathAI; Harvard Medical School (formerly)

PathAI — Founding and Scientific Direction of AI-Powered Pathology PlatformDeep Learning for Pathology Biomarker Discovery — TILs, Fibrosis, and Tumor Architecture

关注 简尼特·罗利 的研究动态

Follow Janet D. Rowley's research updates

留下邮箱，当我们发布与 Janet D. Rowley（University of Chicago (Legacy)）相关的新研究或访谈时，我们会通知你。

我们不会泄露你的信息，也不会发送无关内容。随时可以退订。

Explore More Experts

Discover the researchers shaping the future of cancer treatment

Browse All ExpertsRead Research Insights