Jan A. Burger
扬·伯格
MD, PhD
Professor of Medicine, Department of Leukemia医学教授，白血病科
👥Biography 个人简介
Dr. Jan Burger is an internationally recognized CLL specialist and the world's leading expert on ibrutinib resistance mechanisms. His laboratory discovered BTK C481S and PLCG2 mutations conferring ibrutinib resistance in CLL, foundational work enabling the development of covalent and non-covalent BTK inhibitors and combination strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Ibrutinib Resistance Mechanisms
First described BTK C481S cysteine mutation as the dominant mechanism of acquired ibrutinib resistance in CLL, a landmark discovery driving next-generation BTK inhibitor development including acalabrutinib and pirtobrutinib.
CLL Microenvironment Biology
Demonstrated that CXCR4 and VLA-4 mediated tissue retention in bone marrow and lymph node niches protects CLL cells from therapy, supporting CXCR4 antagonist combinations to mobilize and sensitize CLL cells.
Representative Works 代表性著作
Clonal Evolution in Patients with CLL Developing Resistance to BTK Inhibition
Nature Communications (2016)
Defined mutational landscape of ibrutinib resistance in CLL, identifying BTK C481S and PLCG2 gain-of-function mutations through serial genomic analysis.
Ibrutinib as Initial Therapy for Patients with CLL
New England Journal of Medicine (2015)
First trial demonstrating superior outcomes of ibrutinib over chlorambucil as frontline therapy in older CLL patients, including those with high-risk genomic features.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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