James Chih-Hsin Yang
楊志新
MD, PhD
Director, Department of Oncology; Professor of Medicine肿瘤科主任；医学教授
👥Biography 个人简介
Prof. James Chih-Hsin Yang is a globally recognized expert in EGFR and HER2-driven lung cancer. He has led pivotal trials of poziotinib, mobocertinib, and trastuzumab deruxtecan in HER2-mutated NSCLC, and contributed landmark analyses of EGFR exon 20 insertions that shaped regulatory approvals in Asia and globally.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HER2-mutated Lung Cancer
Led DESTINY-Lung01 and related trials establishing trastuzumab deruxtecan as the first approved therapy for HER2-mutated NSCLC, revolutionizing treatment for this previously orphan population.
EGFR Exon 20 Insertions
Conducted pivotal studies of mobocertinib in EGFR exon 20 insertion-mutated NSCLC, providing the efficacy and safety data underpinning FDA and regulatory approvals in Asia.
Novel EGFR-targeted Agents
Pioneered early clinical evaluation of multiple-generation EGFR inhibitors and antibody-drug conjugates in Asian NSCLC, defining optimal dosing and biomarker-driven patient selection.
Representative Works 代表性著作
Trastuzumab Deruxtecan in HER2-Mutant Non-Small-Cell Lung Cancer (DESTINY-Lung01)
New England Journal of Medicine (2021)
Demonstrated 55% ORR of T-DXd in HER2-mutated NSCLC, the highest reported for any agent in this setting and the basis for the first HER2-targeted lung cancer approval.
Mobocertinib in EGFR Exon 20 Insertion-Positive NSCLC (EXCLAIM)
Journal of Clinical Oncology (2022)
Showed 28% ORR with durable responses of mobocertinib in EGFR exon 20-mutated NSCLC after platinum failure, supporting accelerated FDA approval.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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