J. Michael Bishop
迈克尔·毕晓普
MD
Professor Emeritus, Department of Microbiology & Immunology; Chancellor Emeritus, UCSF微生物学与免疫学系荣休教授；UCSF荣休校长
👥Biography 个人简介
J. Michael Bishop shared the 1989 Nobel Prize in Physiology or Medicine with Harold Varmus for the discovery that oncogenes originate from normal cellular proto-oncogenes. Working at UCSF, Bishop and Varmus showed that the cancer-causing src gene of Rous sarcoma virus has a normal cellular counterpart present in healthy organisms across species — the c-src proto-oncogene. This discovery established that cancer arises from mutations in our own genes rather than exclusively from foreign viral elements, revolutionizing the conceptual and molecular basis of cancer biology. Bishop also served as Chancellor of UCSF from 1998 to 2009.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Cellular Origin of Oncogenes
Co-discovered that the v-src oncogene of Rous sarcoma virus has a normal cellular homologue (c-src), proving cancer genes are corrupted versions of host genes.
Src Tyrosine Kinase Biology
Contributed foundational knowledge of the Src family of non-receptor tyrosine kinases, now established drug targets across multiple cancers.
UCSF Scientific Leadership
As Chancellor of UCSF, built the Mission Bay research campus and expanded translational cancer research programs that continue to drive therapeutic development.
Representative Works 代表性著作
Nucleotide Sequence Relationships of Avian RNA Tumor Viruses: Specificity of Oligonucleotide Fingerprints
Proceedings of the National Academy of Sciences (1973)
Early foundational paper establishing molecular tools for studying retroviral oncogenes that enabled the Nobel Prize discovery.
How to Win the Nobel Prize: An Unexpected Life in Science
Harvard University Press (Book) (2003)
Memoir and scientific reflection on the discovery of proto-oncogenes and the culture of biomedical research.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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