Irving Weissman
欧文·魏斯曼
MD
Virginia and D.K. Ludwig Professor of Clinical Investigation in Cancer Research; Director, Institute for Stem Cell Biology and Regenerative Medicine斯坦福大学干细胞生物学研究所所长，Ludwig讲席教授
👥Biography 个人简介
Irving Weissman is the discoverer of the CD47 'don't eat me' signal, revealing how cancer cells exploit innate immune checkpoints to evade macrophage-mediated phagocytosis. His Stanford laboratory showed that CD47 is uniformly overexpressed on cancer stem cells and most solid tumors, and that anti-CD47 antibodies restore macrophage-mediated cancer cell killing. This work launched a major new class of innate immune checkpoint inhibitors now in clinical trials for multiple cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CD47 Discovery in Cancer
Identified CD47 overexpression as a universal cancer evasion strategy, showing tumor cells use CD47-SIRPα signaling to inhibit macrophage phagocytosis and dendritic cell cross-presentation.
Anti-CD47 Therapy
Developed anti-CD47 antibody (Hu5F9-G4 / magrolimab) and demonstrated tumor regression in preclinical models and early Phase I/II clinical trials across AML, lymphoma, and solid tumors.
Calreticulin Pro-Phagocytic Signal
Showed that balanced pro-phagocytic (calreticulin) and anti-phagocytic (CD47) signals on cancer cells dictate macrophage recognition, elucidating the phagocytic checkpoint concept.
Representative Works 代表性著作
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
Cell (2009)
Established CD47 as both a therapeutic target and prognostic biomarker on AML stem cells, initiating the anti-CD47 antibody therapy field.
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications
Current Opinion in Immunology (2018)
Comprehensive review of the phagocytic checkpoint mechanism and clinical development of magrolimab in combination with rituximab and azacitidine.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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